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Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to al...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892743/ https://www.ncbi.nlm.nih.gov/pubmed/24490083 http://dx.doi.org/10.1155/2013/853737 |
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author | Leung, Wai Yin Jensen, Matthew B. |
author_facet | Leung, Wai Yin Jensen, Matthew B. |
author_sort | Leung, Wai Yin |
collection | PubMed |
description | Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to allow for healing of brain tissue. Many potential restorative treatments may affect, and be affected by, angiogenesis, so accurate quantification of this outcome is needed. We performed a systematic review of histological methods to quantify angiogenesis after cerebral infarction. We found reports of the use of a variety of histological and general and immunostaining techniques in conjunction with a variety of analysis methods. We found no direct comparison studies and concluded that more research is needed to optimize the assessment of this important stroke outcome. |
format | Online Article Text |
id | pubmed-3892743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38927432014-02-02 Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review Leung, Wai Yin Jensen, Matthew B. ISRN Neurol Review Article Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to allow for healing of brain tissue. Many potential restorative treatments may affect, and be affected by, angiogenesis, so accurate quantification of this outcome is needed. We performed a systematic review of histological methods to quantify angiogenesis after cerebral infarction. We found reports of the use of a variety of histological and general and immunostaining techniques in conjunction with a variety of analysis methods. We found no direct comparison studies and concluded that more research is needed to optimize the assessment of this important stroke outcome. Hindawi Publishing Corporation 2013-12-30 /pmc/articles/PMC3892743/ /pubmed/24490083 http://dx.doi.org/10.1155/2013/853737 Text en Copyright © 2013 W. Y. Leung and M. B. Jensen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Leung, Wai Yin Jensen, Matthew B. Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review |
title | Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review |
title_full | Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review |
title_fullStr | Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review |
title_full_unstemmed | Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review |
title_short | Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review |
title_sort | histological quantification of angiogenesis after focal cerebral infarction: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892743/ https://www.ncbi.nlm.nih.gov/pubmed/24490083 http://dx.doi.org/10.1155/2013/853737 |
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