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Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review

Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to al...

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Detalles Bibliográficos
Autores principales: Leung, Wai Yin, Jensen, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892743/
https://www.ncbi.nlm.nih.gov/pubmed/24490083
http://dx.doi.org/10.1155/2013/853737
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author Leung, Wai Yin
Jensen, Matthew B.
author_facet Leung, Wai Yin
Jensen, Matthew B.
author_sort Leung, Wai Yin
collection PubMed
description Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to allow for healing of brain tissue. Many potential restorative treatments may affect, and be affected by, angiogenesis, so accurate quantification of this outcome is needed. We performed a systematic review of histological methods to quantify angiogenesis after cerebral infarction. We found reports of the use of a variety of histological and general and immunostaining techniques in conjunction with a variety of analysis methods. We found no direct comparison studies and concluded that more research is needed to optimize the assessment of this important stroke outcome.
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spelling pubmed-38927432014-02-02 Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review Leung, Wai Yin Jensen, Matthew B. ISRN Neurol Review Article Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to allow for healing of brain tissue. Many potential restorative treatments may affect, and be affected by, angiogenesis, so accurate quantification of this outcome is needed. We performed a systematic review of histological methods to quantify angiogenesis after cerebral infarction. We found reports of the use of a variety of histological and general and immunostaining techniques in conjunction with a variety of analysis methods. We found no direct comparison studies and concluded that more research is needed to optimize the assessment of this important stroke outcome. Hindawi Publishing Corporation 2013-12-30 /pmc/articles/PMC3892743/ /pubmed/24490083 http://dx.doi.org/10.1155/2013/853737 Text en Copyright © 2013 W. Y. Leung and M. B. Jensen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Leung, Wai Yin
Jensen, Matthew B.
Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
title Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
title_full Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
title_fullStr Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
title_full_unstemmed Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
title_short Histological Quantification of Angiogenesis after Focal Cerebral Infarction: A Systematic Review
title_sort histological quantification of angiogenesis after focal cerebral infarction: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892743/
https://www.ncbi.nlm.nih.gov/pubmed/24490083
http://dx.doi.org/10.1155/2013/853737
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