Cargando…

Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line

Medullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch signaling has a tumor suppressor role in NETs. The potential therapeutic effect of thiocoraline on the activation of the Notch pathway in an MTC cell line (TT) was investi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tesfazghi, Sara, Eide, Jacob, Dammalapati, Ajitha, Korlesky, Colin, Wyche, Thomas P, Bugni, Tim S, Chen, Herbert, Jaskula-Sztul, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Science Inc 2013
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892805/ https://www.ncbi.nlm.nih.gov/pubmed/24403239 http://dx.doi.org/10.1002/cam4.118

Ejemplares similares

Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo
por: Wyche, Thomas P., et al.
Publicado: (2014)

Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo
por: Jang, Samuel, et al.
Publicado: (2017)

Antineoplastic effects of histone deacetylase inhibitors in neuroendocrine cancer cells are mediated through transcriptional regulation of Notch1 by activator protein 1
por: Jang, Samuel, et al.
Publicado: (2017)

Chrysin suppresses the achaete-scute complex-like1 and alters the neuroendocrine phenotype of carcinoids
por: Somnay, Yash R., et al.
Publicado: (2015)

2018 Synaptic vesicle 2 receptors as a novel targets for neuroendocrine cancer therapy
por: Jaskula-Sztul, Renata, et al.
Publicado: (2018)

Preoperative Identification of Medullary Thyroid Carcinoma (MTC): Clinical Validation of the Afirma MTC RNA-Sequencing Classifier
por: Randolph, Gregory W., et al.
Publicado: (2022)

Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT
por: Baldini, Enke, et al.
Publicado: (2011)

Mode of action of thiocoraline, a natural marine compound with anti-tumour activity
por: Erba, E, et al.
Publicado: (1999)

Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline
por: Camunas-Soler, Joan, et al.
Publicado: (2015)

Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells
por: Aburjania, Zviadi, et al.
Publicado: (2020)

Dual-Targeted Extracellular Vesicles to Facilitate Combined Therapies for Neuroendocrine Cancer Treatment
por: Si, Yingnan, et al.
Publicado: (2020)

Ex Vivo Modeling of Human Neuroendocrine Tumors in Tissue Surrogates
por: Herring, Brendon, et al.
Publicado: (2021)

Anti-SSTR2 Antibody-drug Conjugate for Neuroendocrine Tumor Therapy
por: Si, Yingnan, et al.
Publicado: (2020)

Predictive Value of 99MTC-hynic-toc Scintigraphy in Lung Neuroendocrine Tumor Diagnosis
por: Boutsikou, Efimia, et al.
Publicado: (2019)

Genetic risk association of CDKN1A and RET gene SNPs with medullary thyroid carcinoma: Results from the largest MTC cohort and meta‐analysis
por: Mishra, Vasudha, et al.
Publicado: (2019)

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas
por: Meder, Lydia, et al.
Publicado: (2015)

Heterogeneity of Vascular Endothelial Cells, De Novo Arteriogenesis and Therapeutic Implications in Pancreatic Neuroendocrine Tumors
por: Ren, Bin, et al.
Publicado: (2019)

Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations
por: Wong, Nelson K Y, et al.
Publicado: (2012)

Comparison of 99mTc radiolabeled somatostatin antagonist with [(68) Ga]Ga-DOTA-TATE in a patient with advanced neuroendocrine tumor
por: Opalinska, Marta, et al.
Publicado: (2023)

Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions
por: Larsen, Michele Campaigne, et al.
Publicado: (2020)

Solwaric Acids A and B, Antibacterial Aromatic Acids from a Marine Solwaraspora sp.
por: Ellis, Gregory A., et al.
Publicado: (2014)

Natural Product Discovery Using Planes of Principal Component Analysis in R (PoPCAR)
por: Chanana, Shaurya, et al.
Publicado: (2017)

Notch Signaling in Neuroendocrine Tumors
por: Crabtree, Judy S., et al.
Publicado: (2016)

The tunnel TT6 and TT70 towards TT60
por: CERN PhotoLab
Publicado: (1979)

Up-regulation of miR-34c-5p inhibits nasopharyngeal carcinoma cells by mediating NOTCH1
por: Xu, Xin, et al.
Publicado: (2020)

STYX/FBXW7 axis participates in the development of endometrial cancer cell via Notch–mTOR signaling pathway
por: Liu, Liheng, et al.
Publicado: (2020)

The Diagnostic Efficiency of 99mTc-EDDA/HYNIC-Octreotate SPECT-CT in Comparison with 111In-Pentetrotide in the Detection of Neuroendocrine Tumours
por: Koçyiğit Deveci, Emel, et al.
Publicado: (2013)

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
por: Wong, Chung, et al.
Publicado: (2012)

Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine‐non‐neuroendocrine neoplasm
por: Zhang, Panpan, et al.
Publicado: (2021)

LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial–mesenchymal transition
por: Kim, Lee Kyung, et al.
Publicado: (2021)

Absence of the RET+3:T allele in the MTC patients
por: Borun, Pawel, et al.
Publicado: (2012)

Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children
por: Çelik, Tanju, et al.
Publicado: (2014)

Prognostic value of neuron-specific enolase in patients with advanced and metastatic non-neuroendocrine non-small cell lung cancer
por: Yan, Peng, et al.
Publicado: (2021)

Activation of the Nuclear Factor E2-Related Factor 2 Pathway by Novel Natural Products Halomadurones A–D and a Synthetic Analogue
por: Wyche, Thomas P., et al.
Publicado: (2013)

Host Control of Symbiont Natural Product Chemistry in Cryptic Populations of the Tunicate Lissoclinum patella
por: Kwan, Jason C., et al.
Publicado: (2014)

Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer
por: Choi, Stephen Yiu Chuen, et al.
Publicado: (2018)

IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation
por: Pan, Li, et al.
Publicado: (2020)

Protein Kinase D1 Signaling in Cancer Stem Cells with Epithelial-Mesenchymal Plasticity
por: Guo, Yichen, et al.
Publicado: (2022)

Recent measurement of tt+V and tt+HF
por: Kuhl, Thorsten
Publicado: (2019)

MPDZ promotes DLL4-induced Notch signaling during angiogenesis
por: Tetzlaff, Fabian, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p37j4ssh1bnlnpma1folt754s0