Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain

Rett syndrome is a neurological disorder caused by mutations in the MECP2 gene.  MeCP2 transcripts are alternatively spliced to generate two protein isoforms (MeCP2_e1 and MeCP2_e2) that differ at their N-termini. Whilst mRNAs for both forms are expressed ubiquitously, the one for MeCP2_e1 is more a...

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Detalles Bibliográficos
Autores principales: Kaddoum, Lara, Panayotis, Nicolas, Mazarguil, Honoré, Giglia-Mari, Giuseppina, Roux, Jean Christophe, Joly, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892919/
https://www.ncbi.nlm.nih.gov/pubmed/24555100
http://dx.doi.org/10.12688/f1000research.2-204.v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892919/
https://www.ncbi.nlm.nih.gov/pubmed/24555100
http://dx.doi.org/10.12688/f1000research.2-204.v1

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