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Isoform-specific anti-MeCP2 antibodies confirm that expression of the e1 isoform strongly predominates in the brain
Rett syndrome is a neurological disorder caused by mutations in the MECP2 gene. MeCP2 transcripts are alternatively spliced to generate two protein isoforms (MeCP2_e1 and MeCP2_e2) that differ at their N-termini. Whilst mRNAs for both forms are expressed ubiquitously, the one for MeCP2_e1 is more a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
F1000Research
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892919/ https://www.ncbi.nlm.nih.gov/pubmed/24555100 http://dx.doi.org/10.12688/f1000research.2-204.v1 |