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IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo

TCR ligation and co-stimulation induce cellular division; however, optimal accumulation of effector CD8 T cells requires direct inflammatory signaling by signal 3 cytokines, such as IL-12 or type I IFNs. Although in vitro studies suggest that IL-12/type I IFN may enhance T cell survival or early pro...

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Detalles Bibliográficos
Autores principales:	Starbeck-Miller, Gabriel R., Xue, Hai-Hui, Harty, John T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892973/ https://www.ncbi.nlm.nih.gov/pubmed/24367005 http://dx.doi.org/10.1084/jem.20130901

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