Cargando…

A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges

PURPOSE: Scalp EEG remains the standard clinical procedure for the diagnosis of epilepsy. Manual detection of inter-ictal epileptiform discharges (IEDs) is slow and cumbersome, and few automated methods are used to assist in practice. This is mostly due to low sensitivities, high false positive rate...

Descripción completa

Detalles Bibliográficos
Autores principales: Lodder, Shaun S., van Putten, Michel J. A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893182/
https://www.ncbi.nlm.nih.gov/pubmed/24454813
http://dx.doi.org/10.1371/journal.pone.0085180
_version_ 1782299636758740992
author Lodder, Shaun S.
van Putten, Michel J. A. M.
author_facet Lodder, Shaun S.
van Putten, Michel J. A. M.
author_sort Lodder, Shaun S.
collection PubMed
description PURPOSE: Scalp EEG remains the standard clinical procedure for the diagnosis of epilepsy. Manual detection of inter-ictal epileptiform discharges (IEDs) is slow and cumbersome, and few automated methods are used to assist in practice. This is mostly due to low sensitivities, high false positive rates, or a lack of trust in the automated method. In this study we aim to find a solution that will make computer assisted detection more efficient than conventional methods, while preserving the detection certainty of a manual search. METHODS: Our solution consists of two phases. First, a detection phase finds all events similar to epileptiform activity by using a large database of template waveforms. Individual template detections are combined to form “IED nominations”, each with a corresponding certainty value based on the reliability of their contributing templates. The second phase uses the ten nominations with highest certainty and presents them to the reviewer one by one for confirmation. Confirmations are used to update certainty values of the remaining nominations, and another iteration is performed where ten nominations with the highest certainty are presented. This continues until the reviewer is satisfied with what has been seen. Reviewer feedback is also used to update template accuracies globally and improve future detections. KEY FINDINGS: Using the described method and fifteen evaluation EEGs (241 IEDs), one third of all inter-ictal events were shown after one iteration, half after two iterations, and 74%, 90%, and 95% after 5, 10 and 15 iterations respectively. Reviewing fifteen iterations for the 20–30 min recordings 1took approximately 5 min. SIGNIFICANCE: The proposed method shows a practical approach for combining automated detection with visual searching for inter-ictal epileptiform activity. Further evaluation is needed to verify its clinical feasibility and measure the added value it presents.
format Online
Article
Text
id pubmed-3893182
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-38931822014-01-21 A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges Lodder, Shaun S. van Putten, Michel J. A. M. PLoS One Research Article PURPOSE: Scalp EEG remains the standard clinical procedure for the diagnosis of epilepsy. Manual detection of inter-ictal epileptiform discharges (IEDs) is slow and cumbersome, and few automated methods are used to assist in practice. This is mostly due to low sensitivities, high false positive rates, or a lack of trust in the automated method. In this study we aim to find a solution that will make computer assisted detection more efficient than conventional methods, while preserving the detection certainty of a manual search. METHODS: Our solution consists of two phases. First, a detection phase finds all events similar to epileptiform activity by using a large database of template waveforms. Individual template detections are combined to form “IED nominations”, each with a corresponding certainty value based on the reliability of their contributing templates. The second phase uses the ten nominations with highest certainty and presents them to the reviewer one by one for confirmation. Confirmations are used to update certainty values of the remaining nominations, and another iteration is performed where ten nominations with the highest certainty are presented. This continues until the reviewer is satisfied with what has been seen. Reviewer feedback is also used to update template accuracies globally and improve future detections. KEY FINDINGS: Using the described method and fifteen evaluation EEGs (241 IEDs), one third of all inter-ictal events were shown after one iteration, half after two iterations, and 74%, 90%, and 95% after 5, 10 and 15 iterations respectively. Reviewing fifteen iterations for the 20–30 min recordings 1took approximately 5 min. SIGNIFICANCE: The proposed method shows a practical approach for combining automated detection with visual searching for inter-ictal epileptiform activity. Further evaluation is needed to verify its clinical feasibility and measure the added value it presents. Public Library of Science 2014-01-15 /pmc/articles/PMC3893182/ /pubmed/24454813 http://dx.doi.org/10.1371/journal.pone.0085180 Text en © 2014 Lodder, van Putten http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lodder, Shaun S.
van Putten, Michel J. A. M.
A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges
title A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges
title_full A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges
title_fullStr A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges
title_full_unstemmed A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges
title_short A Self-Adapting System for the Automated Detection of Inter-Ictal Epileptiform Discharges
title_sort self-adapting system for the automated detection of inter-ictal epileptiform discharges
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893182/
https://www.ncbi.nlm.nih.gov/pubmed/24454813
http://dx.doi.org/10.1371/journal.pone.0085180
work_keys_str_mv AT loddershauns aselfadaptingsystemfortheautomateddetectionofinterictalepileptiformdischarges
AT vanputtenmicheljam aselfadaptingsystemfortheautomateddetectionofinterictalepileptiformdischarges
AT loddershauns selfadaptingsystemfortheautomateddetectionofinterictalepileptiformdischarges
AT vanputtenmicheljam selfadaptingsystemfortheautomateddetectionofinterictalepileptiformdischarges