Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4/ligase IV during chromosomal translocation formation

Chromosomal translocations in hematologic and mesenchymal tumors form overwhelmingly by nonhomologous end-joining (NHEJ). Canonical NHEJ, essential for the repair of radiation-induced and some programmed double-strand breaks (DSBs), requires the Xrcc4/ligase IV complex. For other DSBs, the requireme...

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Detalles Bibliográficos
Autores principales: Simsek, Deniz, Jasin, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893185/
https://www.ncbi.nlm.nih.gov/pubmed/20208544
http://dx.doi.org/10.1038/nsmb.1773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893185/
https://www.ncbi.nlm.nih.gov/pubmed/20208544
http://dx.doi.org/10.1038/nsmb.1773

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