Cargando…

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4/ligase IV during chromosomal translocation formation

Chromosomal translocations in hematologic and mesenchymal tumors form overwhelmingly by nonhomologous end-joining (NHEJ). Canonical NHEJ, essential for the repair of radiation-induced and some programmed double-strand breaks (DSBs), requires the Xrcc4/ligase IV complex. For other DSBs, the requireme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simsek, Deniz, Jasin, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893185/ https://www.ncbi.nlm.nih.gov/pubmed/20208544 http://dx.doi.org/10.1038/nsmb.1773

Ejemplares similares

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation
por: Simsek, Deniz, et al.
Publicado: (2011)

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining
por: Soni, Aashish, et al.
Publicado: (2014)

Alternative end-joining in BCR gene rearrangements and translocations: Alternative end-joining in BCR gene rearrangements and translocations
por: Bai, Wanyu, et al.
Publicado: (2022)

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency
por: Chang, Howard H. Y., et al.
Publicado: (2016)

Crucial roles for DNA ligase III in mitochondria but not in XRCC1-dependent repair
por: Simsek, Deniz, et al.
Publicado: (2011)

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex
por: Hammel, Michal, et al.
Publicado: (2016)

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
por: Saribasak, Huseyin, et al.
Publicado: (2011)

Radiation-hypersensitive cancer patients do not manifest protein expression abnormalities in components of the nonhomologous end-joining (NHEJ) pathway
por: Leong, T, et al.
Publicado: (2003)

Canonical Non-Homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-Specific Phosphorylation of XRCC4
por: Terasawa, Masahiro, et al.
Publicado: (2014)

XRCC4's interaction with XLF is required for coding (but not signal) end joining
por: Roy, Sunetra, et al.
Publicado: (2012)

The phage T4 DNA ligase mediates bacterial chromosome DSBs repair as single component non-homologous end joining
por: Su, Tianyuan, et al.
Publicado: (2019)

DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates
por: Paul, Katja, et al.
Publicado: (2013)

Translocation of XRCC1 and DNA ligase IIIα from centrosomes to chromosomes in response to DNA damage in mitotic human cells
por: Okano, Satoshi, et al.
Publicado: (2005)

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
por: Liang, Li, et al.
Publicado: (2008)

Repair of chromosomal breaks by NHEJ
por: Reid, Dylan A., et al.
Publicado: (2015)

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
por: Han, Li, et al.
Publicado: (2008)

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
por: Han, Li, et al.
Publicado: (2008)

Highly Precise and Developmentally Programmed Genome Assembly in Paramecium Requires Ligase IV–Dependent End Joining
por: Kapusta, Aurélie, et al.
Publicado: (2011)

Saccharomyces cerevisiae DNA Ligase IV Supports Imprecise End Joining Independently of Its Catalytic Activity
por: Chiruvella, Kishore K., et al.
Publicado: (2013)

The DDN Catalytic Motif Is Required for Metnase Functions in Non-homologous End Joining (NHEJ) Repair and Replication Restart
por: Kim, Hyun-Suk, et al.
Publicado: (2014)

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface
por: Menchon, Grégory, et al.
Publicado: (2016)

Cdk1 Restrains NHEJ through Phosphorylation of XRCC4-like Factor Xlf1
por: Hentges, Pierre, et al.
Publicado: (2014)

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
por: Pan-Hammarström, Qiang, et al.
Publicado: (2005)

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
por: Bennardo, Nicole, et al.
Publicado: (2008)

Comparative analysis of the end-joining activity of several DNA ligases
por: Bauer, Robert J., et al.
Publicado: (2017)

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation
por: Riballo, Enriqueta, et al.
Publicado: (2009)

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ
por: Li, Yi, et al.
Publicado: (2008)

MiR-502 is the first reported miRNA simultaneously targeting two components of the classical non-homologous end joining (C-NHEJ) in pancreatic cell lines
por: Smolinska, Agnieszka, et al.
Publicado: (2020)

How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joining
por: Streb, Patrick, et al.
Publicado: (2023)

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity
por: Olmedo-Pelayo, Joaquín, et al.
Publicado: (2020)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2010)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2013)

Mismatch discrimination and sequence bias during end-joining by DNA ligases
por: Bilotti, Katharina, et al.
Publicado: (2022)

Canonical DNA non-homologous end-joining; capacity versus fidelity
por: Shibata, Atsushi, et al.
Publicado: (2020)

Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia
Publicado: (1991)

Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4
por: Liddiard, Kate, et al.
Publicado: (2016)

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism
por: Laffitte, Marie-Claude N., et al.
Publicado: (2016)

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
por: Gu, Jiafeng, et al.
Publicado: (2007)

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway
por: Xing, Mengtan, et al.
Publicado: (2015)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_p50fqeftog6uf4epplk2qk8u4r