Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

Antibody engineering is increasingly being used to influence the properties of monoclonal antibodies to improve their biotherapeutic potential. One important aspect of this is the modulation of glycosylation as a strategy to improve efficacy. Here, we describe mutations of Y407 in the CH3 domain of...

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Detalles Bibliográficos
Autores principales: Rose, Rebecca J., van Berkel, Patrick H.C., van den Bremer, Ewald T.J., Labrijn, Aran F., Vink, Tom, Schuurman, Janine, Heck, Albert J.R., Parren, Paul W.H.I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893232/
https://www.ncbi.nlm.nih.gov/pubmed/23406897
http://dx.doi.org/10.4161/mabs.23532

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