RHPS4 G-Quadruplex Ligand Induces Anti-Proliferative Effects in Brain Tumor Cells

BACKGROUND: Telomeric 3′ overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 ligands have been designed to directly disrupt telo...

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Detalles Bibliográficos
Autores principales: Lagah, Sunil, Tan, I-Li, Radhakrishnan, Priya, Hirst, Robert A., Ward, Jennifer H., O’Callaghan, Chris, Smith, Stuart J., Stevens, Malcolm F. G., Grundy, Richard G., Rahman, Ruman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893285/
https://www.ncbi.nlm.nih.gov/pubmed/24454961
http://dx.doi.org/10.1371/journal.pone.0086187

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