Cargando…

Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up

OBJECTIVE: Evaluate the effect of antiretroviral therapy (ART) on South African HIV patients’ economic well being, as indicated by symptoms, normal activities, employment, and external support, during the first 5 years on treatment. METHODS: Prospective cohort study of 879 adult patients at public o...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosen, Sydney, Larson, Bruce, Rohr, Julia, Sanne, Ian, Mongwenyana, Constance, Brennan, Alana T., Galárraga, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893293/
https://www.ncbi.nlm.nih.gov/pubmed/24076660
http://dx.doi.org/10.1097/QAD.0000000000000053
_version_ 1782299660312903680
author Rosen, Sydney
Larson, Bruce
Rohr, Julia
Sanne, Ian
Mongwenyana, Constance
Brennan, Alana T.
Galárraga, Omar
author_facet Rosen, Sydney
Larson, Bruce
Rohr, Julia
Sanne, Ian
Mongwenyana, Constance
Brennan, Alana T.
Galárraga, Omar
author_sort Rosen, Sydney
collection PubMed
description OBJECTIVE: Evaluate the effect of antiretroviral therapy (ART) on South African HIV patients’ economic well being, as indicated by symptoms, normal activities, employment, and external support, during the first 5 years on treatment. METHODS: Prospective cohort study of 879 adult patients at public or nongovernmental clinics enrolled before ART initiation or on ART less than 6 months and followed for 5.5 years or less. Patients were interviewed during routine clinic visits. Outcomes were estimated using population-averaged logistic regression and reported as proportions of the cohort experiencing outcomes by duration on ART. RESULTS: For patients remaining in care, outcomes improved continuously and substantially, with all differences between baseline and 5 years statistically significant (P < 0.05) and continued significant improvement between year 3 and year 5. The probability of reporting pain last week fell from 69% during the three months before starting ART to 17% after 5 years on ART and fatigue from 62 to 7%. The probability of not being able to perform normal activities in the previous week fell from 47 to 5% and of being employed increased from 32 to 44%; difficulty with job performance among those employed fell from 56 to 6%. As health improved, the probability of relying on a caretaker declined from 81 to less than 1%, and receipt of a disability grant, which initially increased, fell slightly over time on ART. CONCLUSION: Results from one of the longest prospective cohorts tracking economic outcomes of HIV treatment in Africa suggest continuous improvement during the first 5 years on treatment, confirming the sustained economic benefits of providing large-scale treatment.
format Online
Article
Text
id pubmed-3893293
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-38932932014-01-16 Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up Rosen, Sydney Larson, Bruce Rohr, Julia Sanne, Ian Mongwenyana, Constance Brennan, Alana T. Galárraga, Omar AIDS Epidemiology and Social OBJECTIVE: Evaluate the effect of antiretroviral therapy (ART) on South African HIV patients’ economic well being, as indicated by symptoms, normal activities, employment, and external support, during the first 5 years on treatment. METHODS: Prospective cohort study of 879 adult patients at public or nongovernmental clinics enrolled before ART initiation or on ART less than 6 months and followed for 5.5 years or less. Patients were interviewed during routine clinic visits. Outcomes were estimated using population-averaged logistic regression and reported as proportions of the cohort experiencing outcomes by duration on ART. RESULTS: For patients remaining in care, outcomes improved continuously and substantially, with all differences between baseline and 5 years statistically significant (P < 0.05) and continued significant improvement between year 3 and year 5. The probability of reporting pain last week fell from 69% during the three months before starting ART to 17% after 5 years on ART and fatigue from 62 to 7%. The probability of not being able to perform normal activities in the previous week fell from 47 to 5% and of being employed increased from 32 to 44%; difficulty with job performance among those employed fell from 56 to 6%. As health improved, the probability of relying on a caretaker declined from 81 to less than 1%, and receipt of a disability grant, which initially increased, fell slightly over time on ART. CONCLUSION: Results from one of the longest prospective cohorts tracking economic outcomes of HIV treatment in Africa suggest continuous improvement during the first 5 years on treatment, confirming the sustained economic benefits of providing large-scale treatment. Lippincott Williams & Wilkins 2014-01-28 2014-01-04 /pmc/articles/PMC3893293/ /pubmed/24076660 http://dx.doi.org/10.1097/QAD.0000000000000053 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Epidemiology and Social
Rosen, Sydney
Larson, Bruce
Rohr, Julia
Sanne, Ian
Mongwenyana, Constance
Brennan, Alana T.
Galárraga, Omar
Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
title Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
title_full Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
title_fullStr Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
title_full_unstemmed Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
title_short Effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
title_sort effect of antiretroviral therapy on patients’ economic well being: five-year follow-up
topic Epidemiology and Social
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893293/
https://www.ncbi.nlm.nih.gov/pubmed/24076660
http://dx.doi.org/10.1097/QAD.0000000000000053
work_keys_str_mv AT rosensydney effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup
AT larsonbruce effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup
AT rohrjulia effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup
AT sanneian effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup
AT mongwenyanaconstance effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup
AT brennanalanat effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup
AT galarragaomar effectofantiretroviraltherapyonpatientseconomicwellbeingfiveyearfollowup