Cargando…
Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea
PURPOSE: End-of-dose failure (EOD) is a clinically common observation and many cancer patients increase the frequency of opioid administration. Fentanyl matrix use is known to be effective in patients with chronic cancer pain. To measure the effectiveness of increase in a single dose of fentanyl mat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893323/ https://www.ncbi.nlm.nih.gov/pubmed/24453998 http://dx.doi.org/10.4143/crt.2013.45.4.263 |
_version_ | 1782299663621160960 |
---|---|
author | Koh, Sung Ae Lee, Kyung Hee Kim, Mi Jung Lee, Kyu Taek Park, Seung Woo Nam, Seung Hyun Ryoo, Hun Mo |
author_facet | Koh, Sung Ae Lee, Kyung Hee Kim, Mi Jung Lee, Kyu Taek Park, Seung Woo Nam, Seung Hyun Ryoo, Hun Mo |
author_sort | Koh, Sung Ae |
collection | PubMed |
description | PURPOSE: End-of-dose failure (EOD) is a clinically common observation and many cancer patients increase the frequency of opioid administration. Fentanyl matrix use is known to be effective in patients with chronic cancer pain. To measure the effectiveness of increase in a single dose of fentanyl matrix in patients whose pain was not controlled sufficiently, we perform this study. MATERIALS AND METHODS: A multi-center, open-label, prospective, observational study was conducted in 30 hospitals in Korea, between August and December 2008. RESULTS: A total of 452 patients were enrolled; 404 patients completed the study. The mean pain intensity decreased from 5.27 at the first visit to 3.37 at the end of the trial. There was a significant difference in pain intensity (p < 0.001) between the first and last visits. The percentage of pain intensity difference was 30.1%. The prevalence of EOD at the first visit was 73% from the 452 enrolled patients. After the use of fentanyl patch, EOD decreased from 73% to 56%. Pain intensity of patients experiencing EOD was 5.64 at the baseline compared to 4.27 in patients without EOD. On final visit, pain intensity in patients with and without EOD was 4.02 and 2.54, respectively. The observed adverse events were mainly nausea, asthenia, constipation and diarrhea. CONCLUSION: This study demonstrated that increasing dose of fentanyl patch decreased pain intensity and decreased the rate of patients experiencing EOD. Thus, fentanyl patch may be an effective modality in cancer patients whose pain was previously not controlled sufficiently; the side effects were as could be expected with an opioid. |
format | Online Article Text |
id | pubmed-3893323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-38933232014-01-17 Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea Koh, Sung Ae Lee, Kyung Hee Kim, Mi Jung Lee, Kyu Taek Park, Seung Woo Nam, Seung Hyun Ryoo, Hun Mo Cancer Res Treat Original Article PURPOSE: End-of-dose failure (EOD) is a clinically common observation and many cancer patients increase the frequency of opioid administration. Fentanyl matrix use is known to be effective in patients with chronic cancer pain. To measure the effectiveness of increase in a single dose of fentanyl matrix in patients whose pain was not controlled sufficiently, we perform this study. MATERIALS AND METHODS: A multi-center, open-label, prospective, observational study was conducted in 30 hospitals in Korea, between August and December 2008. RESULTS: A total of 452 patients were enrolled; 404 patients completed the study. The mean pain intensity decreased from 5.27 at the first visit to 3.37 at the end of the trial. There was a significant difference in pain intensity (p < 0.001) between the first and last visits. The percentage of pain intensity difference was 30.1%. The prevalence of EOD at the first visit was 73% from the 452 enrolled patients. After the use of fentanyl patch, EOD decreased from 73% to 56%. Pain intensity of patients experiencing EOD was 5.64 at the baseline compared to 4.27 in patients without EOD. On final visit, pain intensity in patients with and without EOD was 4.02 and 2.54, respectively. The observed adverse events were mainly nausea, asthenia, constipation and diarrhea. CONCLUSION: This study demonstrated that increasing dose of fentanyl patch decreased pain intensity and decreased the rate of patients experiencing EOD. Thus, fentanyl patch may be an effective modality in cancer patients whose pain was previously not controlled sufficiently; the side effects were as could be expected with an opioid. Korean Cancer Association 2013-12 2013-12-31 /pmc/articles/PMC3893323/ /pubmed/24453998 http://dx.doi.org/10.4143/crt.2013.45.4.263 Text en Copyright © 2013 by the Korean Cancer Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Koh, Sung Ae Lee, Kyung Hee Kim, Mi Jung Lee, Kyu Taek Park, Seung Woo Nam, Seung Hyun Ryoo, Hun Mo Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea |
title | Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea |
title_full | Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea |
title_fullStr | Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea |
title_full_unstemmed | Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea |
title_short | Effect of Dose Escalation with Single Opioid, Fentanyl Matrix in Patients Not Controlling Cancer Pain: A Multicenter, Prospective, Observational Study in Korea |
title_sort | effect of dose escalation with single opioid, fentanyl matrix in patients not controlling cancer pain: a multicenter, prospective, observational study in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893323/ https://www.ncbi.nlm.nih.gov/pubmed/24453998 http://dx.doi.org/10.4143/crt.2013.45.4.263 |
work_keys_str_mv | AT kohsungae effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea AT leekyunghee effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea AT kimmijung effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea AT leekyutaek effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea AT parkseungwoo effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea AT namseunghyun effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea AT ryoohunmo effectofdoseescalationwithsingleopioidfentanylmatrixinpatientsnotcontrollingcancerpainamulticenterprospectiveobservationalstudyinkorea |