Cargando…
Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience
PURPOSE: This study compared the survival outcomes of different treatment methods for the ipsilateral breast of occult breast cancer (OBC) patients with axillary lymph node metastasis. METHODS: A retrospective study was conducted in which forty OBC patients with axillary lymph node metastasis were i...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Breast Cancer Society
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893343/ https://www.ncbi.nlm.nih.gov/pubmed/24454463 http://dx.doi.org/10.4048/jbc.2013.16.4.410 |
_version_ | 1782299668534788096 |
---|---|
author | Woo, Sang Min Son, Byung Ho Lee, Jong Won Kim, Hee Jeong Yu, Jong Han Ko, Beom Seok Sohn, Guiyun Lee, Yu Ra Kim, Hanna Ahn, Sei Hyun Baek, Seung Hee |
author_facet | Woo, Sang Min Son, Byung Ho Lee, Jong Won Kim, Hee Jeong Yu, Jong Han Ko, Beom Seok Sohn, Guiyun Lee, Yu Ra Kim, Hanna Ahn, Sei Hyun Baek, Seung Hee |
author_sort | Woo, Sang Min |
collection | PubMed |
description | PURPOSE: This study compared the survival outcomes of different treatment methods for the ipsilateral breast of occult breast cancer (OBC) patients with axillary lymph node metastasis. METHODS: A retrospective study was conducted in which forty OBC patients with axillary lymph node metastasis were identified out of 15,029 patients who had been diagnosed with a primary breast cancer at between 1992 and 2010. The patients were categorized into three treatment groups based on ipsilateral breast management: breast-conserving surgery (BCS) (n=17), mastectomy (n=12), and nonsurgical intervention with or without radiation therapy (No surgery with or without radiation therapy [No Op±RT]) (n=11). All patients underwent axillary lymph node dissection. Cases were evaluated based on treatment and potential prognostic factors with respect to overall survival (OS) and disease-free survival (DFS). RESULTS: During the follow-up period (median follow-up of 71.5 months), the overall OS and DFS were 76.9% and 74.9%, respectively. The 5-year treatment-specific OS was 72.0% for the BCS group, 74.0% for the mastectomy group, and 87.5% for the No Op±RT group (log-rank p=0.49). The 5-year DFS was 70.6% for the BCS group, 66.7% for the mastectomy group, and 90.9% for the No Op±RT group (log-rank p=0.36). Recurrence rates for the BCS and No Op±RT groups were 5.9% and 18.2%, respectively. Histologic grade and lymph node status were inversely correlated with DFS (log-rank p=0.04 and p<0.01, respectively). CONCLUSION: There was no difference in survival outcomes between the three treatment methods for the ipsilateral breast (mastectomy, BCS, and No Op±RT) of OBC patients with axillary lymph node metastasis. A large-scale multicenter study is needed to validate the results from this small retrospective study. |
format | Online Article Text |
id | pubmed-3893343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Korean Breast Cancer Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-38933432014-01-17 Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience Woo, Sang Min Son, Byung Ho Lee, Jong Won Kim, Hee Jeong Yu, Jong Han Ko, Beom Seok Sohn, Guiyun Lee, Yu Ra Kim, Hanna Ahn, Sei Hyun Baek, Seung Hee J Breast Cancer Original Article PURPOSE: This study compared the survival outcomes of different treatment methods for the ipsilateral breast of occult breast cancer (OBC) patients with axillary lymph node metastasis. METHODS: A retrospective study was conducted in which forty OBC patients with axillary lymph node metastasis were identified out of 15,029 patients who had been diagnosed with a primary breast cancer at between 1992 and 2010. The patients were categorized into three treatment groups based on ipsilateral breast management: breast-conserving surgery (BCS) (n=17), mastectomy (n=12), and nonsurgical intervention with or without radiation therapy (No surgery with or without radiation therapy [No Op±RT]) (n=11). All patients underwent axillary lymph node dissection. Cases were evaluated based on treatment and potential prognostic factors with respect to overall survival (OS) and disease-free survival (DFS). RESULTS: During the follow-up period (median follow-up of 71.5 months), the overall OS and DFS were 76.9% and 74.9%, respectively. The 5-year treatment-specific OS was 72.0% for the BCS group, 74.0% for the mastectomy group, and 87.5% for the No Op±RT group (log-rank p=0.49). The 5-year DFS was 70.6% for the BCS group, 66.7% for the mastectomy group, and 90.9% for the No Op±RT group (log-rank p=0.36). Recurrence rates for the BCS and No Op±RT groups were 5.9% and 18.2%, respectively. Histologic grade and lymph node status were inversely correlated with DFS (log-rank p=0.04 and p<0.01, respectively). CONCLUSION: There was no difference in survival outcomes between the three treatment methods for the ipsilateral breast (mastectomy, BCS, and No Op±RT) of OBC patients with axillary lymph node metastasis. A large-scale multicenter study is needed to validate the results from this small retrospective study. Korean Breast Cancer Society 2013-12 2013-12-31 /pmc/articles/PMC3893343/ /pubmed/24454463 http://dx.doi.org/10.4048/jbc.2013.16.4.410 Text en © 2013 Korean Breast Cancer Society. All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Woo, Sang Min Son, Byung Ho Lee, Jong Won Kim, Hee Jeong Yu, Jong Han Ko, Beom Seok Sohn, Guiyun Lee, Yu Ra Kim, Hanna Ahn, Sei Hyun Baek, Seung Hee Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience |
title | Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience |
title_full | Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience |
title_fullStr | Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience |
title_full_unstemmed | Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience |
title_short | Survival Outcomes of Different Treatment Methods for the Ipsilateral Breast of Occult Breast Cancer Patients with Axillary Lymph Node Metastasis: A Single Center Experience |
title_sort | survival outcomes of different treatment methods for the ipsilateral breast of occult breast cancer patients with axillary lymph node metastasis: a single center experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893343/ https://www.ncbi.nlm.nih.gov/pubmed/24454463 http://dx.doi.org/10.4048/jbc.2013.16.4.410 |
work_keys_str_mv | AT woosangmin survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT sonbyungho survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT leejongwon survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT kimheejeong survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT yujonghan survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT kobeomseok survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT sohnguiyun survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT leeyura survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT kimhanna survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT ahnseihyun survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience AT baekseunghee survivaloutcomesofdifferenttreatmentmethodsfortheipsilateralbreastofoccultbreastcancerpatientswithaxillarylymphnodemetastasisasinglecenterexperience |