Reducing TDP-43 aggregation does not prevent its cytotoxicity

BACKGROUND: TAR DNA-binding protein 43 (TDP-43) is a protein that is involved in the pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In patients with these neurodegenerative diseases, TDP-43 does not remain in its normal nuclear location, but instead fo...

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Detalles Bibliográficos
Autores principales: Liu, Rui, Yang, Guang, Nonaka, Takashi, Arai, Tetsuaki, Jia, William, Cynader, Max S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893365/
https://www.ncbi.nlm.nih.gov/pubmed/24252504
http://dx.doi.org/10.1186/2051-5960-1-49

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