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Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

BACKGROUND: S-nitrosoglutathione (GSNO) serves as a reservoir for nitric oxide (NO) and thus is a key homeostatic regulator of airway smooth muscle tone and inflammation. Decreased levels of GSNO in the lungs of asthmatics have been attributed to increased GSNO catabolism via GSNO reductase (GSNOR)...

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Detalles Bibliográficos
Autores principales:	Blonder, Joan P, Mutka, Sarah C, Sun, Xicheng, Qiu, Jian, Green, Lucia H, Mehra, Navdeep K, Boyanapalli, Ramakrishna, Suniga, Michael, Look, Kirsten, Delany, Chris, Richards, Jane P, Looker, Doug, Scoggin, Charles, Rosenthal, Gary J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893392/ https://www.ncbi.nlm.nih.gov/pubmed/24405692 http://dx.doi.org/10.1186/1471-2466-14-3

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