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Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans

Human choice behavior often reflects a competition between inflexible computationally efficient control on the one hand and a slower more flexible system of control on the other. This distinction is well captured by model-free and model-based reinforcement learning algorithms. Here, studying human s...

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Detalles Bibliográficos
Autores principales: Smittenaar, Peter, FitzGerald, Thomas H.B., Romei, Vincenzo, Wright, Nicholas D., Dolan, Raymond J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893454/
https://www.ncbi.nlm.nih.gov/pubmed/24206669
http://dx.doi.org/10.1016/j.neuron.2013.08.009
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author Smittenaar, Peter
FitzGerald, Thomas H.B.
Romei, Vincenzo
Wright, Nicholas D.
Dolan, Raymond J.
author_facet Smittenaar, Peter
FitzGerald, Thomas H.B.
Romei, Vincenzo
Wright, Nicholas D.
Dolan, Raymond J.
author_sort Smittenaar, Peter
collection PubMed
description Human choice behavior often reflects a competition between inflexible computationally efficient control on the one hand and a slower more flexible system of control on the other. This distinction is well captured by model-free and model-based reinforcement learning algorithms. Here, studying human subjects, we show it is possible to shift the balance of control between these systems by disruption of right dorsolateral prefrontal cortex, such that participants manifest a dominance of the less optimal model-free control. In contrast, disruption of left dorsolateral prefrontal cortex impaired model-based performance only in those participants with low working memory capacity.
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spelling pubmed-38934542014-01-16 Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans Smittenaar, Peter FitzGerald, Thomas H.B. Romei, Vincenzo Wright, Nicholas D. Dolan, Raymond J. Neuron Report Human choice behavior often reflects a competition between inflexible computationally efficient control on the one hand and a slower more flexible system of control on the other. This distinction is well captured by model-free and model-based reinforcement learning algorithms. Here, studying human subjects, we show it is possible to shift the balance of control between these systems by disruption of right dorsolateral prefrontal cortex, such that participants manifest a dominance of the less optimal model-free control. In contrast, disruption of left dorsolateral prefrontal cortex impaired model-based performance only in those participants with low working memory capacity. Cell Press 2013-11-20 /pmc/articles/PMC3893454/ /pubmed/24206669 http://dx.doi.org/10.1016/j.neuron.2013.08.009 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/3.0/).
spellingShingle Report
Smittenaar, Peter
FitzGerald, Thomas H.B.
Romei, Vincenzo
Wright, Nicholas D.
Dolan, Raymond J.
Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans
title Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans
title_full Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans
title_fullStr Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans
title_full_unstemmed Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans
title_short Disruption of Dorsolateral Prefrontal Cortex Decreases Model-Based in Favor of Model-free Control in Humans
title_sort disruption of dorsolateral prefrontal cortex decreases model-based in favor of model-free control in humans
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893454/
https://www.ncbi.nlm.nih.gov/pubmed/24206669
http://dx.doi.org/10.1016/j.neuron.2013.08.009
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