Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

BACKGROUND: Chronic mucous hypersecretion (CMH) contributes to COPD exacerbations and increased risk for lung cancer. Because methylation of gene promoters in sputum has been shown to be associated with lung cancer risk, we tested whether such methylation was more common in persons with CMH. METHODS...

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Detalles Bibliográficos
Autores principales: Bruse, Shannon, Petersen, Hans, Weissfeld, Joel, Picchi, Maria, Willink, Randall, Do, Kieu, Siegfried, Jill, Belinsky, Steven A, Tesfaigzi, Yohannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893562/
https://www.ncbi.nlm.nih.gov/pubmed/24405663
http://dx.doi.org/10.1186/1465-9921-15-2

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