The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

BACKGROUND: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk f...

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Detalles Bibliográficos
Autores principales: Stutzbach, Lauren D, Xie, Sharon X, Naj, Adam C, Albin, Roger, Gilman, Sid, Lee, Virginia M Y, Trojanowski, John Q, Devlin, Bernie, Schellenberg, Gerard D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893579/
https://www.ncbi.nlm.nih.gov/pubmed/24252572
http://dx.doi.org/10.1186/2051-5960-1-31

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