Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG

BACKGROUND: Point mutations in genes encoding NADP(+)-dependent isocitrate dehydrogenases (especially IDH1) are common in lower grade diffuse gliomas and secondary glioblastomas and occur early during tumor development. The contribution of these mutations to gliomagenesis is not completely understoo...

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Detalles Bibliográficos
Autores principales: Navis, Anna C, Niclou, Simone P, Fack, Fred, Stieber, Daniel, van Lith, Sanne, Verrijp, Kiek, Wright, Alan, Stauber, Jonathan, Tops, Bastiaan, Otte-Holler, Irene, Wevers, Ron A, van Rooij, Arno, Pusch, Stefan, von Deimling, Andreas, Tigchelaar, Wikky, van Noorden, Cornelis JF, Wesseling, Pieter, Leenders, William PJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893588/
https://www.ncbi.nlm.nih.gov/pubmed/24252742
http://dx.doi.org/10.1186/2051-5960-1-18

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