Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

BACKGROUND: A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caused by TDP-43 mutations. TDP-43 is involved in processing of both coding RNAs an...

Descripción completa

Detalles Bibliográficos
Autores principales: Freischmidt, Axel, Müller, Kathrin, Ludolph, Albert C, Weishaupt, Jochen H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893596/
https://www.ncbi.nlm.nih.gov/pubmed/24252274
http://dx.doi.org/10.1186/2051-5960-1-42

Ejemplares similares

Ejemplares similares