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Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population
Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. Th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893736/ https://www.ncbi.nlm.nih.gov/pubmed/24489547 http://dx.doi.org/10.1155/2013/215454 |
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author | Lamba, Divjot Singh Kaur, Ravneet Basu, Sabita |
author_facet | Lamba, Divjot Singh Kaur, Ravneet Basu, Sabita |
author_sort | Lamba, Divjot Singh |
collection | PubMed |
description | Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied. Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency was Fy(a) (87.3%) and Fy(b) (58.3%). Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients. |
format | Online Article Text |
id | pubmed-3893736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38937362014-02-02 Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population Lamba, Divjot Singh Kaur, Ravneet Basu, Sabita Adv Hematol Research Article Background. Racial differences in blood group antigen distribution are common and may result in striking and interesting findings. These differences in blood group antigen distribution are important due to their influence on the clinical practice of transfusion medicine. Study Design and Methods. This is a prospective study, involving 1000 healthy regular repeat voluntary blood donors associated with the department. The clinically significant minor blood group antigens of these donors were studied. Results. Out of 1000 healthy regular repeat voluntary blood donors, 93% were D positive and 2.8% were K positive. Amongst the Rh antigens, e was the most common (99%), followed by D (93%), C (85.1%), c (62.3%), and E (21.5%). Within the MNS blood group system, antigen frequency was M (88%), N (57.5%), S (57.8%), and s (87.5%). Within the Duffy blood group system, antigen frequency was Fy(a) (87.3%) and Fy(b) (58.3%). Conclusions. This data base will help us to prevent alloimmunisation in young females, pregnant women, and patients who are expected to require repeated transfusions in life by providing them with antigen matched blood. Antigen negative blood can also be made available without delay to already alloimmunized multitransfused patients. Hindawi Publishing Corporation 2013 2013-12-09 /pmc/articles/PMC3893736/ /pubmed/24489547 http://dx.doi.org/10.1155/2013/215454 Text en Copyright © 2013 Divjot Singh Lamba et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lamba, Divjot Singh Kaur, Ravneet Basu, Sabita Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
title | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
title_full | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
title_fullStr | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
title_full_unstemmed | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
title_short | Clinically Significant Minor Blood Group Antigens amongst North Indian Donor Population |
title_sort | clinically significant minor blood group antigens amongst north indian donor population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893736/ https://www.ncbi.nlm.nih.gov/pubmed/24489547 http://dx.doi.org/10.1155/2013/215454 |
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