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Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours

This study presents a radiobiological formalism for the evaluation of the treatment plans with respect to the probability of controlling tumours treated with stereotactic radiosurgery accounting for possible infiltrations of malignant cells beyond the margins of the delineated target. Treatments pla...

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Detalles Bibliográficos
Autores principales: Sandström, Helena, Dasu, Alexandru, Toma-Dasu, Iuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893765/
https://www.ncbi.nlm.nih.gov/pubmed/24490086
http://dx.doi.org/10.1155/2013/527251
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author Sandström, Helena
Dasu, Alexandru
Toma-Dasu, Iuliana
author_facet Sandström, Helena
Dasu, Alexandru
Toma-Dasu, Iuliana
author_sort Sandström, Helena
collection PubMed
description This study presents a radiobiological formalism for the evaluation of the treatment plans with respect to the probability of controlling tumours treated with stereotactic radiosurgery accounting for possible infiltrations of malignant cells beyond the margins of the delineated target. Treatments plans devised for three anaplastic astrocytoma cases were assumed for this study representing cases with different difficulties for target coverage. Several scenarios were considered regarding the infiltration patterns. Tumour response was described in terms of tumour control probability (TCP) assuming a Poisson model taking into account the initial number of clonogenic cells and the cell survival. The results showed the strong impact of the pattern of infiltration of tumour clonogens outside the delineated target on the outcome of the treatment. The treatment plan has to take into account the existence of the possible microscopic disease around the visible lesion; otherwise the high gradients around the target effectively prevent the sterilisation of the microscopic spread leading to low probability of control, in spite of the high dose delivered to the target. From this perspective, the proposed framework offers a further criterion for the evaluation of stereotactic radiosurgery plans taking into account the possible infiltration of tumour cells around the visible target.
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spelling pubmed-38937652014-02-02 Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours Sandström, Helena Dasu, Alexandru Toma-Dasu, Iuliana ISRN Oncol Research Article This study presents a radiobiological formalism for the evaluation of the treatment plans with respect to the probability of controlling tumours treated with stereotactic radiosurgery accounting for possible infiltrations of malignant cells beyond the margins of the delineated target. Treatments plans devised for three anaplastic astrocytoma cases were assumed for this study representing cases with different difficulties for target coverage. Several scenarios were considered regarding the infiltration patterns. Tumour response was described in terms of tumour control probability (TCP) assuming a Poisson model taking into account the initial number of clonogenic cells and the cell survival. The results showed the strong impact of the pattern of infiltration of tumour clonogens outside the delineated target on the outcome of the treatment. The treatment plan has to take into account the existence of the possible microscopic disease around the visible lesion; otherwise the high gradients around the target effectively prevent the sterilisation of the microscopic spread leading to low probability of control, in spite of the high dose delivered to the target. From this perspective, the proposed framework offers a further criterion for the evaluation of stereotactic radiosurgery plans taking into account the possible infiltration of tumour cells around the visible target. Hindawi Publishing Corporation 2013-12-29 /pmc/articles/PMC3893765/ /pubmed/24490086 http://dx.doi.org/10.1155/2013/527251 Text en Copyright © 2013 Helena Sandström et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sandström, Helena
Dasu, Alexandru
Toma-Dasu, Iuliana
Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours
title Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours
title_full Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours
title_fullStr Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours
title_full_unstemmed Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours
title_short Radiobiological Framework for the Evaluation of Stereotactic Radiosurgery Plans for Invasive Brain Tumours
title_sort radiobiological framework for the evaluation of stereotactic radiosurgery plans for invasive brain tumours
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893765/
https://www.ncbi.nlm.nih.gov/pubmed/24490086
http://dx.doi.org/10.1155/2013/527251
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