NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent...

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Detalles Bibliográficos
Autores principales: He, Lin, Cai, Zhi-Hua, Pian, Ji-Xin, Du, Guang-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893873/
https://www.ncbi.nlm.nih.gov/pubmed/24489517
http://dx.doi.org/10.1155/2013/890187
Descripción
Sumario:N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.

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