NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones

N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent...

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Detalles Bibliográficos
Autores principales: He, Lin, Cai, Zhi-Hua, Pian, Ji-Xin, Du, Guang-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893873/
https://www.ncbi.nlm.nih.gov/pubmed/24489517
http://dx.doi.org/10.1155/2013/890187
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author He, Lin
Cai, Zhi-Hua
Pian, Ji-Xin
Du, Guang-Fen
author_facet He, Lin
Cai, Zhi-Hua
Pian, Ji-Xin
Du, Guang-Fen
author_sort He, Lin
collection PubMed
description N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.
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spelling pubmed-38938732014-02-02 NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones He, Lin Cai, Zhi-Hua Pian, Ji-Xin Du, Guang-Fen ScientificWorldJournal Research Article N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield. Hindawi Publishing Corporation 2013-12-31 /pmc/articles/PMC3893873/ /pubmed/24489517 http://dx.doi.org/10.1155/2013/890187 Text en Copyright © 2013 Lin He et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
He, Lin
Cai, Zhi-Hua
Pian, Ji-Xin
Du, Guang-Fen
NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
title NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
title_full NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
title_fullStr NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
title_full_unstemmed NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
title_short NHCs Catalyzed Hydrophosphonylation of α-Ketoesters and α-Trifluoromethyl Ketones
title_sort nhcs catalyzed hydrophosphonylation of α-ketoesters and α-trifluoromethyl ketones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893873/
https://www.ncbi.nlm.nih.gov/pubmed/24489517
http://dx.doi.org/10.1155/2013/890187
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AT pianjixin nhcscatalyzedhydrophosphonylationofaketoestersandatrifluoromethylketones
AT duguangfen nhcscatalyzedhydrophosphonylationofaketoestersandatrifluoromethylketones

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