Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma

Rhabdomyosarcoma is the most commonly occurring soft-tissue sarcoma in childhood. Most rhabdomyosarcoma falls into one of two biologically distinct subgroups represented by alveolar or embryonal histology. The alveolar subtype harbors a translocation-mediated PAX3:FOXO1A fusion gene and has an extre...

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Detalles Bibliográficos
Autores principales: Kikuchi, Ken, Hettmer, Simone, Aslam, M. Imran, Michalek, Joel E., Laub, Wolfram, Wilky, Breelyn A., Loeb, David M., Rubin, Brian P., Wagers, Amy J., Keller, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894165/
https://www.ncbi.nlm.nih.gov/pubmed/24453992
http://dx.doi.org/10.1371/journal.pgen.1004107

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