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Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?
DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway, which has long been considered to be error-prone. However, recent data have pointed to the intrinsic precision of NHEJ. Three reasons...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894167/ https://www.ncbi.nlm.nih.gov/pubmed/24453986 http://dx.doi.org/10.1371/journal.pgen.1004086 |