Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway, which has long been considered to be error-prone. However, recent data have pointed to the intrinsic precision of NHEJ. Three reasons...

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Detalles Bibliográficos
Autores principales: Bétermier, Mireille, Bertrand, Pascale, Lopez, Bernard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894167/
https://www.ncbi.nlm.nih.gov/pubmed/24453986
http://dx.doi.org/10.1371/journal.pgen.1004086

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