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Pooled Screening for Synergistic Interactions Subject to Blocking and Noise
The complex molecular networks in the cell can give rise to surprising interactions: gene deletions that are synthetically lethal, gene overexpressions that promote stemness or differentiation, synergistic drug interactions that heighten potency. Yet, the number of actual interactions is dwarfed by...
Autores principales: | Li, Kyle, Precup, Doina, Perkins, Theodore J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894196/ https://www.ncbi.nlm.nih.gov/pubmed/24454940 http://dx.doi.org/10.1371/journal.pone.0085864 |
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