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Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism

Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(Δpepc)), which was only achievable when malate, a r...

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Detalles Bibliográficos
Autores principales:	Storm, Janet, Sethia, Sonal, Blackburn, Gavin J., Chokkathukalam, Achuthanunni, Watson, David G., Breitling, Rainer, Coombs, Graham H., Müller, Sylke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894211/ https://www.ncbi.nlm.nih.gov/pubmed/24453970 http://dx.doi.org/10.1371/journal.ppat.1003876

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