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The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data
BACKGROUND/AIMS: Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension,...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association for the Study of the Liver
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894436/ https://www.ncbi.nlm.nih.gov/pubmed/24459641 http://dx.doi.org/10.3350/cmh.2013.19.4.370 |
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author | Hong, Won Ki Kim, Moon Young Baik, Soon Koo Shin, Seung Yong Kim, Jung Min Kang, Yong Seok Lim, Yoo Li Kim, Young Ju Cho, Youn Zoo Hwang, Hye Won Lee, Jin Hyung Chae, Myeong Hun Kim, Hyoun A Kang, Hye Won Kwon, Sang Ok |
author_facet | Hong, Won Ki Kim, Moon Young Baik, Soon Koo Shin, Seung Yong Kim, Jung Min Kang, Yong Seok Lim, Yoo Li Kim, Young Ju Cho, Youn Zoo Hwang, Hye Won Lee, Jin Hyung Chae, Myeong Hun Kim, Hyoun A Kang, Hye Won Kwon, Sang Ok |
author_sort | Hong, Won Ki |
collection | PubMed |
description | BACKGROUND/AIMS: Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. METHODS: LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. RESULTS: A strong positive correlation between LSM and HVPG was observed in the overall population (r(2)=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. CONCLUSIONS: LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis. |
format | Online Article Text |
id | pubmed-3894436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Association for the Study of the Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-38944362014-01-23 The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data Hong, Won Ki Kim, Moon Young Baik, Soon Koo Shin, Seung Yong Kim, Jung Min Kang, Yong Seok Lim, Yoo Li Kim, Young Ju Cho, Youn Zoo Hwang, Hye Won Lee, Jin Hyung Chae, Myeong Hun Kim, Hyoun A Kang, Hye Won Kwon, Sang Ok Clin Mol Hepatol Original Article BACKGROUND/AIMS: Liver stiffness measurement (LSM) has been proposed as a non-invasive method for estimating the severity of fibrosis and the complications of cirrhosis. Measurement of the hepatic venous pressure gradient (HVPG) is the gold standard for assessing the presence of portal hypertension, but its invasiveness limits its clinical application. In this study we evaluated the relationship between LSM and HVPG, and the predictive value of LSM for clinically significant portal hypertension (CSPH) and severe portal hypertension in cirrhosis. METHODS: LSM was performed with transient elastography in 59 consecutive cirrhotic patients who underwent hemodynamic HVPG investigations. CSPH and severe portal hypertension were defined as HVPG ≥10 and ≥12 mmHg, respectively. Linear regression analysis was performed to evaluate the relationship between LSM and HVPG. Diagnostic values were analyzed based on receiver operating characteristic (ROC) curves. RESULTS: A strong positive correlation between LSM and HVPG was observed in the overall population (r(2)=0.496, P<0.0001). The area under the ROC curve (AUROC) for the prediction of CSPH (HVPG ≥10 mmHg) was 0.851, and the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for an LSM cutoff value of 21.95 kPa were 82.5%, 73.7%, 86.8%, and 66.7%, respectively. The AUROC at prediction of severe portal hypertension (HVPG ≥12 mmHg) was 0.877, and the sensitivity, specificity, PPV, and NPV at LSM cutoff value of 24.25 kPa were 82.9%, 70.8%, 80.6%, and 73.9%, respectively. CONCLUSIONS: LSM exhibited a significant correlation with HVPG in patients with cirrhosis. LSM could be a non-invasive method for predicting CSPH and severe portal hypertension in Korean patients with liver cirrhosis. The Korean Association for the Study of the Liver 2013-12 2013-12-28 /pmc/articles/PMC3894436/ /pubmed/24459641 http://dx.doi.org/10.3350/cmh.2013.19.4.370 Text en Copyright © 2013 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Hong, Won Ki Kim, Moon Young Baik, Soon Koo Shin, Seung Yong Kim, Jung Min Kang, Yong Seok Lim, Yoo Li Kim, Young Ju Cho, Youn Zoo Hwang, Hye Won Lee, Jin Hyung Chae, Myeong Hun Kim, Hyoun A Kang, Hye Won Kwon, Sang Ok The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title | The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_full | The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_fullStr | The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_full_unstemmed | The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_short | The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data |
title_sort | usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: korean data |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894436/ https://www.ncbi.nlm.nih.gov/pubmed/24459641 http://dx.doi.org/10.3350/cmh.2013.19.4.370 |
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