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Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications
Nitric oxide has been implicated in many physiologic processes that influence both acute and long-term control of kidney function. Its net effect in the kidney is to promote natriuresis and diuresis, contributing to adaptation to variations of dietary salt intake and maintenance of normal blood pres...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Electrolyte and Blood Pressure Research
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894485/ https://www.ncbi.nlm.nih.gov/pubmed/24459519 http://dx.doi.org/10.5049/EBP.2008.6.1.27 |
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author | Lee, JongUn |
author_facet | Lee, JongUn |
author_sort | Lee, JongUn |
collection | PubMed |
description | Nitric oxide has been implicated in many physiologic processes that influence both acute and long-term control of kidney function. Its net effect in the kidney is to promote natriuresis and diuresis, contributing to adaptation to variations of dietary salt intake and maintenance of normal blood pressure. A pretreatment with nitric oxide donors or L-arginine may prevent the ischemic acute renal injury. In chronic kidney diseases, the systolic blood pressure is correlated with the plasma level of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase. A reduced production and biological action of nitric oxide is associated with an elevation of arterial pressure, and conversely, an exaggerated activity may represent a compensatory mechanism to mitigate the hypertension. |
format | Online Article Text |
id | pubmed-3894485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Korean Society of Electrolyte and Blood Pressure Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-38944852014-01-23 Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications Lee, JongUn Electrolyte Blood Press Review Article Nitric oxide has been implicated in many physiologic processes that influence both acute and long-term control of kidney function. Its net effect in the kidney is to promote natriuresis and diuresis, contributing to adaptation to variations of dietary salt intake and maintenance of normal blood pressure. A pretreatment with nitric oxide donors or L-arginine may prevent the ischemic acute renal injury. In chronic kidney diseases, the systolic blood pressure is correlated with the plasma level of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase. A reduced production and biological action of nitric oxide is associated with an elevation of arterial pressure, and conversely, an exaggerated activity may represent a compensatory mechanism to mitigate the hypertension. The Korean Society of Electrolyte and Blood Pressure Research 2008-06 2008-06-30 /pmc/articles/PMC3894485/ /pubmed/24459519 http://dx.doi.org/10.5049/EBP.2008.6.1.27 Text en Copyright © 2008 The Korean Society of Electrolyte and Blood Pressure Research |
spellingShingle | Review Article Lee, JongUn Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications |
title | Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications |
title_full | Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications |
title_fullStr | Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications |
title_full_unstemmed | Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications |
title_short | Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications |
title_sort | nitric oxide in the kidney : its physiological role and pathophysiological implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894485/ https://www.ncbi.nlm.nih.gov/pubmed/24459519 http://dx.doi.org/10.5049/EBP.2008.6.1.27 |
work_keys_str_mv | AT leejongun nitricoxideinthekidneyitsphysiologicalroleandpathophysiologicalimplications |