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Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone

Vasopressin, angiotensin II (AngII), and aldosterone are essential hormones in the regulation of body fluid homeostatsis. We examined the effects of AngII or aldosterone on the regulation of body water balance. We demonstrated that 1) short-term treatment with AngII in the primary cultured inner med...

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Autores principales: Lee, Byung-Heon, Kwon, Tae-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Electrolyte and Blood Pressure Research 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894501/
https://www.ncbi.nlm.nih.gov/pubmed/24459495
http://dx.doi.org/10.5049/EBP.2007.5.1.15
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author Lee, Byung-Heon
Kwon, Tae-Hwan
author_facet Lee, Byung-Heon
Kwon, Tae-Hwan
author_sort Lee, Byung-Heon
collection PubMed
description Vasopressin, angiotensin II (AngII), and aldosterone are essential hormones in the regulation of body fluid homeostatsis. We examined the effects of AngII or aldosterone on the regulation of body water balance. We demonstrated that 1) short-term treatment with AngII in the primary cultured inner medullary collecting duct cells played a role in the regulation of AQP2 targeting to the plasma membrane through AT1 receptor activation. This potentiated the effects of dDAVP on cAMP accumulation, AQP2 phosphorylation, and AQP2 plasma membrane targeting; 2) pharmacological blockade of the AngII AT1 receptor in rats co-treated with dDAVP and dietary NaCl-restriction (to induce high plasma endogenous AngII) resulted in an increase in urine production, a decrease in urine osmolality, and blunted the dDAVP-induced upregulation of AQP2; 3) long-term aldosterone infusion in normal rats or in rats with diabetes insipidus was associated with polyuria and decreased urine concentration, accompanied by decreased apical but increased basolateral AQP2 labeling intensity in the connecting tubule and cortical collecting duct; and 4) in contrast to the effects of dDAVP and AngII, short-term aldosterone treatment does not alter the intracellular distribution of AQP2. In conclusion, angiotensin II, and aldosterone could play a role in the regulation of renal water reabsorption by changing intracellular AQP2 targeting and/or AQP2 abundance, in addition to the vasopressin.
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spelling pubmed-38945012014-01-23 Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone Lee, Byung-Heon Kwon, Tae-Hwan Electrolyte Blood Press Review Article Vasopressin, angiotensin II (AngII), and aldosterone are essential hormones in the regulation of body fluid homeostatsis. We examined the effects of AngII or aldosterone on the regulation of body water balance. We demonstrated that 1) short-term treatment with AngII in the primary cultured inner medullary collecting duct cells played a role in the regulation of AQP2 targeting to the plasma membrane through AT1 receptor activation. This potentiated the effects of dDAVP on cAMP accumulation, AQP2 phosphorylation, and AQP2 plasma membrane targeting; 2) pharmacological blockade of the AngII AT1 receptor in rats co-treated with dDAVP and dietary NaCl-restriction (to induce high plasma endogenous AngII) resulted in an increase in urine production, a decrease in urine osmolality, and blunted the dDAVP-induced upregulation of AQP2; 3) long-term aldosterone infusion in normal rats or in rats with diabetes insipidus was associated with polyuria and decreased urine concentration, accompanied by decreased apical but increased basolateral AQP2 labeling intensity in the connecting tubule and cortical collecting duct; and 4) in contrast to the effects of dDAVP and AngII, short-term aldosterone treatment does not alter the intracellular distribution of AQP2. In conclusion, angiotensin II, and aldosterone could play a role in the regulation of renal water reabsorption by changing intracellular AQP2 targeting and/or AQP2 abundance, in addition to the vasopressin. The Korean Society of Electrolyte and Blood Pressure Research 2007-06 2007-06-30 /pmc/articles/PMC3894501/ /pubmed/24459495 http://dx.doi.org/10.5049/EBP.2007.5.1.15 Text en Copyright © 2007 The Korean Society of Electrolyte and Blood Pressure Research
spellingShingle Review Article
Lee, Byung-Heon
Kwon, Tae-Hwan
Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
title Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
title_full Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
title_fullStr Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
title_full_unstemmed Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
title_short Regulation of AQP2 in Collecting Duct : An emphasis on the Effects of Angiotensin II or Aldosterone
title_sort regulation of aqp2 in collecting duct : an emphasis on the effects of angiotensin ii or aldosterone
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894501/
https://www.ncbi.nlm.nih.gov/pubmed/24459495
http://dx.doi.org/10.5049/EBP.2007.5.1.15
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