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RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure

Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs. siRNA is recognized and processed by Ago2 and C3PO, endonucleases of the RNA-induced silencing complex (RISC). RISC cleaves passeng...

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Detalles Bibliográficos
Autores principales:	Allison, Simon J, Milner, Jo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Methods: Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894584/ https://www.ncbi.nlm.nih.gov/pubmed/24399205 http://dx.doi.org/10.1038/mtna.2013.68

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