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Overexpression of Dimethylarginine Dimethylaminohydrolase 1 Attenuates Airway Inflammation in a Mouse Model of Asthma

Levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, are increased in lung, sputum, exhaled breath condensate and plasma samples from asthma patients. ADMA is metabolized primarily by dimethylarginine dimethylaminohydrolase 1 (DDAH1) and DDAH2. We determine...

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Detalles Bibliográficos
Autores principales:	Kinker, Kayla G., Gibson, Aaron M., Bass, Stacey A., Day, Brandy P., Deng, Jingyuan, Medvedovic, Mario, Figueroa, Julio A. Landero, Hershey, Gurjit K. Khurana, Chen, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894860/ https://www.ncbi.nlm.nih.gov/pubmed/24465497 http://dx.doi.org/10.1371/journal.pone.0085148

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