Targeting GRP75 Improves HSP90 Inhibitor Efficacy by Enhancing p53-Mediated Apoptosis in Hepatocellular Carcinoma

Heat shock protein 90 (HSP90) inhibitors are potential drugs for cancer therapy. The inhibition of HSP90 on cancer cell growth largely through degrading client proteins, like Akt and p53, therefore, triggering cancer cell apoptosis. Here, we show that the HSP90 inhibitor 17-AAG can induce the expres...

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Detalles Bibliográficos
Autores principales: Guo, Weiwei, Yan, Lichong, Yang, Ling, Liu, Xiaoyu, E, Qiukai, Gao, Peiye, Ye, Xiaofei, Liu, Wen, Zuo, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894982/
https://www.ncbi.nlm.nih.gov/pubmed/24465691
http://dx.doi.org/10.1371/journal.pone.0085766

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