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CKIP-1 Is an Intrinsic Negative Regulator of T-Cell Activation through an Interaction with CARMA1

The transcription factor NF-κB plays a key regulatory role in lymphocyte activation and generation of immune response. Stimulation of T cell receptor (TCR) induces phosphorylation of CARMA1 by PKCθ, resulting in formation of CARMA1-Bcl10-MALT1 (CBM) complex at lipid rafts and subsequently leading to...

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Detalles Bibliográficos
Autores principales:	Sakamoto, Takashi, Kobayashi, Masayuki, Tada, Kohei, Shinohara, Masanobu, Io, Katsuhiro, Nagata, Kayoko, Iwai, Fumie, Takiuchi, Yoko, Arai, Yasuyuki, Yamashita, Kouhei, Shindo, Keisuke, Kadowaki, Norimitsu, Koyanagi, Yoshio, Takaori-Kondo, Akifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894987/ https://www.ncbi.nlm.nih.gov/pubmed/24465689 http://dx.doi.org/10.1371/journal.pone.0085762

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