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Arctigenin Inhibits Osteoclast Differentiation and Function by Suppressing Both Calcineurin-Dependent and Osteoblastic Cell-Dependent NFATc1 Pathways
Arctigenin, a lignan-derived compound, is a constituent of the seeds of Arctium lappa. Arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. Here, we showed that arctigenin inhibited the action of nuclear factor of activated T-cel...
Autores principales: | Yamashita, Teruhito, Uehara, Shunsuke, Udagawa, Nobuyuki, Li, Feng, Kadota, Shigetoshi, Esumi, Hiroyasu, Kobayashi, Yasuhiro, Takahashi, Naoyuki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895012/ https://www.ncbi.nlm.nih.gov/pubmed/24465763 http://dx.doi.org/10.1371/journal.pone.0085878 |
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