Identification of Proteins Related to Epigenetic Regulation in the Malignant Transformation of Aberrant Karyotypic Human Embryonic Stem Cells by Quantitative Proteomics

Previous reports have demonstrated that human embryonic stem cells (hESCs) tend to develop genomic alterations and progress to a malignant state during long-term in vitro culture. This raises concerns of the clinical safety in using cultured hESCs. However, transformed hESCs might serve as an excell...

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Detalles Bibliográficos
Autores principales: Sun, Yi, Yang, Yixuan, Zeng, Sicong, Tan, Yueqiu, Lu, Guangxiu, Lin, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895013/
https://www.ncbi.nlm.nih.gov/pubmed/24465727
http://dx.doi.org/10.1371/journal.pone.0085823

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