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Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt

Highly pathogenic avian influenza (AI) due to H5N1 virus was first reported in Egypt in February 2006; since then, the government has allowed avian influenza vaccination in poultry. The present study evaluated the impact of AI vaccination in terms of cumulative annual flock immunity (CAFI): the perc...

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Autores principales: El Masry, Ihab, Rijks, Jolianne, Peyre, Marisa, Taylor, Nick, Lubroth, Juan, Jobre, Yilma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895176/
https://www.ncbi.nlm.nih.gov/pubmed/23868547
http://dx.doi.org/10.1007/s11250-013-0446-8
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author El Masry, Ihab
Rijks, Jolianne
Peyre, Marisa
Taylor, Nick
Lubroth, Juan
Jobre, Yilma
author_facet El Masry, Ihab
Rijks, Jolianne
Peyre, Marisa
Taylor, Nick
Lubroth, Juan
Jobre, Yilma
author_sort El Masry, Ihab
collection PubMed
description Highly pathogenic avian influenza (AI) due to H5N1 virus was first reported in Egypt in February 2006; since then, the government has allowed avian influenza vaccination in poultry. The present study evaluated the impact of AI vaccination in terms of cumulative annual flock immunity (CAFI): the percentage of bird × weeks protected by immunity. This evaluation took account of the combined effects of vaccination coverage, vaccine efficacy (VE), and different characteristics of household poultry production on the effectiveness of the adopted vaccination strategy (VS), and provided alternative options for improvement. The evaluation used a population and vaccination model that calculates the CAFI. Participatory approaches were employed in 21 villages to develop the vaccination and flock parameters required for the model. The adopted VS were compared in the model with three alternative VS scenarios in terms of the CAFI. Vaccination coverage varied among villages but was generally low (between 1 and 48 %; median 14 %). Under the adopted VS, the CAFI predicted for the villages ranged from 2 to 31 %. It was concluded that despite the enormous effort put into rural household poultry AI vaccination by the Egyptian government, village CAFI is unlikely to be maintained at the levels required to significantly reduce the virus load and restrict transmission. In HPAI-endemic countries that consider AI vaccination as one of the disease control options, the high cost of mass AI vaccination campaigns and their achievable benefits must be compared with other available control measures, which may include targeted vaccination. Achievable vaccination coverage, VE and the different characteristics of commercial and household (village) poultry production are key parameters determining the feasibility and cost-effectiveness of different AI vaccination strategies.
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spelling pubmed-38951762014-01-22 Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt El Masry, Ihab Rijks, Jolianne Peyre, Marisa Taylor, Nick Lubroth, Juan Jobre, Yilma Trop Anim Health Prod Regular Articles Highly pathogenic avian influenza (AI) due to H5N1 virus was first reported in Egypt in February 2006; since then, the government has allowed avian influenza vaccination in poultry. The present study evaluated the impact of AI vaccination in terms of cumulative annual flock immunity (CAFI): the percentage of bird × weeks protected by immunity. This evaluation took account of the combined effects of vaccination coverage, vaccine efficacy (VE), and different characteristics of household poultry production on the effectiveness of the adopted vaccination strategy (VS), and provided alternative options for improvement. The evaluation used a population and vaccination model that calculates the CAFI. Participatory approaches were employed in 21 villages to develop the vaccination and flock parameters required for the model. The adopted VS were compared in the model with three alternative VS scenarios in terms of the CAFI. Vaccination coverage varied among villages but was generally low (between 1 and 48 %; median 14 %). Under the adopted VS, the CAFI predicted for the villages ranged from 2 to 31 %. It was concluded that despite the enormous effort put into rural household poultry AI vaccination by the Egyptian government, village CAFI is unlikely to be maintained at the levels required to significantly reduce the virus load and restrict transmission. In HPAI-endemic countries that consider AI vaccination as one of the disease control options, the high cost of mass AI vaccination campaigns and their achievable benefits must be compared with other available control measures, which may include targeted vaccination. Achievable vaccination coverage, VE and the different characteristics of commercial and household (village) poultry production are key parameters determining the feasibility and cost-effectiveness of different AI vaccination strategies. Springer Netherlands 2013-07-19 2014 /pmc/articles/PMC3895176/ /pubmed/23868547 http://dx.doi.org/10.1007/s11250-013-0446-8 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Regular Articles
El Masry, Ihab
Rijks, Jolianne
Peyre, Marisa
Taylor, Nick
Lubroth, Juan
Jobre, Yilma
Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt
title Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt
title_full Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt
title_fullStr Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt
title_full_unstemmed Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt
title_short Modelling influenza A H5N1 vaccination strategy scenarios in the household poultry sector in Egypt
title_sort modelling influenza a h5n1 vaccination strategy scenarios in the household poultry sector in egypt
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895176/
https://www.ncbi.nlm.nih.gov/pubmed/23868547
http://dx.doi.org/10.1007/s11250-013-0446-8
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