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The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction. About 20–30 % of cases are inherited in a dominant manner. Mutations in the microtubule-associated protein tau g...

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Detalles Bibliográficos
Autores principales:	Iovino, Mariangela, Pfisterer, Ulrich, Holton, Janice L., Lashley, Tammaryn, Swingler, Robert J., Calo, Laura, Treacy, Rebecca, Revesz, Tamas, Parmar, Malin, Goedert, Michel, Muqit, Miratul M. K., Spillantini, Maria Grazia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895181/ https://www.ncbi.nlm.nih.gov/pubmed/24292008 http://dx.doi.org/10.1007/s00401-013-1219-1

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