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Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group
Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895219/ https://www.ncbi.nlm.nih.gov/pubmed/24264598 http://dx.doi.org/10.1007/s00401-013-1213-7 |
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author | Gottardo, Nicholas G. Hansford, Jordan R. McGlade, Jacqueline P. Alvaro, Frank Ashley, David M. Bailey, Simon Baker, David L. Bourdeaut, Franck Cho, Yoon-Jae Clay, Moira Clifford, Steven C. Cohn, Richard J. Cole, Catherine H. Dallas, Peter B. Downie, Peter Doz, François Ellison, David W. Endersby, Raelene Fisher, Paul G. Hassall, Timothy Heath, John A. Hii, Hilary L. Jones, David T. W. Junckerstorff, Reimar Kellie, Stewart Kool, Marcel Kotecha, Rishi S. Lichter, Peter Laughton, Stephen J. Lee, Sharon McCowage, Geoff Northcott, Paul A. Olson, James M. Packer, Roger J. Pfister, Stefan M. Pietsch, Torsten Pizer, Barry Pomeroy, Scott L. Remke, Marc Robinson, Giles W. Rutkowski, Stefan Schoep, Tobias Shelat, Anang A. Stewart, Clinton F. Sullivan, Michael Taylor, Michael D. Wainwright, Brandon Walwyn, Thomas Weiss, William A. Williamson, Dan Gajjar, Amar |
author_facet | Gottardo, Nicholas G. Hansford, Jordan R. McGlade, Jacqueline P. Alvaro, Frank Ashley, David M. Bailey, Simon Baker, David L. Bourdeaut, Franck Cho, Yoon-Jae Clay, Moira Clifford, Steven C. Cohn, Richard J. Cole, Catherine H. Dallas, Peter B. Downie, Peter Doz, François Ellison, David W. Endersby, Raelene Fisher, Paul G. Hassall, Timothy Heath, John A. Hii, Hilary L. Jones, David T. W. Junckerstorff, Reimar Kellie, Stewart Kool, Marcel Kotecha, Rishi S. Lichter, Peter Laughton, Stephen J. Lee, Sharon McCowage, Geoff Northcott, Paul A. Olson, James M. Packer, Roger J. Pfister, Stefan M. Pietsch, Torsten Pizer, Barry Pomeroy, Scott L. Remke, Marc Robinson, Giles W. Rutkowski, Stefan Schoep, Tobias Shelat, Anang A. Stewart, Clinton F. Sullivan, Michael Taylor, Michael D. Wainwright, Brandon Walwyn, Thomas Weiss, William A. Williamson, Dan Gajjar, Amar |
author_sort | Gottardo, Nicholas G. |
collection | PubMed |
description | Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5–10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization’s classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children’s Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics. Medulloblastoma Down Under 2013 was an effective forum for meaningful discussion, which resulted in enhancing international collaborative clinical and translational research of this rare disease. This template could be applied to other fields to devise global action plans addressing all aspects of a disease, from improved disease classification, treatment stratification, and drug targeting to superior treatment regimens to be assessed in cooperative international clinical trials. |
format | Online Article Text |
id | pubmed-3895219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-38952192014-01-22 Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group Gottardo, Nicholas G. Hansford, Jordan R. McGlade, Jacqueline P. Alvaro, Frank Ashley, David M. Bailey, Simon Baker, David L. Bourdeaut, Franck Cho, Yoon-Jae Clay, Moira Clifford, Steven C. Cohn, Richard J. Cole, Catherine H. Dallas, Peter B. Downie, Peter Doz, François Ellison, David W. Endersby, Raelene Fisher, Paul G. Hassall, Timothy Heath, John A. Hii, Hilary L. Jones, David T. W. Junckerstorff, Reimar Kellie, Stewart Kool, Marcel Kotecha, Rishi S. Lichter, Peter Laughton, Stephen J. Lee, Sharon McCowage, Geoff Northcott, Paul A. Olson, James M. Packer, Roger J. Pfister, Stefan M. Pietsch, Torsten Pizer, Barry Pomeroy, Scott L. Remke, Marc Robinson, Giles W. Rutkowski, Stefan Schoep, Tobias Shelat, Anang A. Stewart, Clinton F. Sullivan, Michael Taylor, Michael D. Wainwright, Brandon Walwyn, Thomas Weiss, William A. Williamson, Dan Gajjar, Amar Acta Neuropathol Meeting Report Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled, resulting in reduced quality of life due to treatment-related side effects, which are a major concern in survivors. The vast amount of genomic and molecular data generated over the last 5–10 years encourages optimism that improved risk stratification and new molecular targets will improve outcomes. It is now clear that medulloblastoma is not a single-disease entity, but instead consists of at least four distinct molecular subgroups: WNT/Wingless, Sonic Hedgehog, Group 3, and Group 4. The Medulloblastoma Down Under 2013 meeting, which convened at Bunker Bay, Australia, brought together 50 leading clinicians and scientists. The 2-day agenda included focused sessions on pathology and molecular stratification, genomics and mouse models, high-throughput drug screening, and clinical trial design. The meeting established a global action plan to translate novel biologic insights and drug targeting into treatment regimens to improve outcomes. A consensus was reached in several key areas, with the most important being that a novel classification scheme for medulloblastoma based on the four molecular subgroups, as well as histopathologic features, should be presented for consideration in the upcoming fifth edition of the World Health Organization’s classification of tumours of the central nervous system. Three other notable areas of agreement were as follows: (1) to establish a central repository of annotated mouse models that are readily accessible and freely available to the international research community; (2) to institute common eligibility criteria between the Children’s Oncology Group and the International Society of Paediatric Oncology Europe and initiate joint or parallel clinical trials; (3) to share preliminary high-throughput screening data across discovery labs to hasten the development of novel therapeutics. Medulloblastoma Down Under 2013 was an effective forum for meaningful discussion, which resulted in enhancing international collaborative clinical and translational research of this rare disease. This template could be applied to other fields to devise global action plans addressing all aspects of a disease, from improved disease classification, treatment stratification, and drug targeting to superior treatment regimens to be assessed in cooperative international clinical trials. Springer Berlin Heidelberg 2013-11-22 2014 /pmc/articles/PMC3895219/ /pubmed/24264598 http://dx.doi.org/10.1007/s00401-013-1213-7 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Meeting Report Gottardo, Nicholas G. Hansford, Jordan R. McGlade, Jacqueline P. Alvaro, Frank Ashley, David M. Bailey, Simon Baker, David L. Bourdeaut, Franck Cho, Yoon-Jae Clay, Moira Clifford, Steven C. Cohn, Richard J. Cole, Catherine H. Dallas, Peter B. Downie, Peter Doz, François Ellison, David W. Endersby, Raelene Fisher, Paul G. Hassall, Timothy Heath, John A. Hii, Hilary L. Jones, David T. W. Junckerstorff, Reimar Kellie, Stewart Kool, Marcel Kotecha, Rishi S. Lichter, Peter Laughton, Stephen J. Lee, Sharon McCowage, Geoff Northcott, Paul A. Olson, James M. Packer, Roger J. Pfister, Stefan M. Pietsch, Torsten Pizer, Barry Pomeroy, Scott L. Remke, Marc Robinson, Giles W. Rutkowski, Stefan Schoep, Tobias Shelat, Anang A. Stewart, Clinton F. Sullivan, Michael Taylor, Michael D. Wainwright, Brandon Walwyn, Thomas Weiss, William A. Williamson, Dan Gajjar, Amar Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group |
title | Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group |
title_full | Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group |
title_fullStr | Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group |
title_full_unstemmed | Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group |
title_short | Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group |
title_sort | medulloblastoma down under 2013: a report from the third annual meeting of the international medulloblastoma working group |
topic | Meeting Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895219/ https://www.ncbi.nlm.nih.gov/pubmed/24264598 http://dx.doi.org/10.1007/s00401-013-1213-7 |
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