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Subcutaneous implants for long-acting drug therapy in laboratory animals may generate unintended drug reservoirs

BACKGROUND: Long-acting therapy in laboratory animals offers advantages over the current practice of 2-3 daily drug injections. Yet little is known about the disintegration of biodegradable drug implants in rodents. OBJECTIVE: Compare bioavailability of buprenorphine with the biodegradation of lipid...

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Detalles Bibliográficos
Autores principales:	Guarnieri, Michael, Tyler, Betty M., DeTolla, Louis, Zhao, Ming, Kobrin, Barry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895292/ https://www.ncbi.nlm.nih.gov/pubmed/24459402 http://dx.doi.org/10.4103/0975-7406.124315

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