GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli

BACKGROUND: Smoothened (Smo), which possesses a structural similarity with classic G-protein coupled receptors (GPCR), is the most important molecular target in Hedgehog (Hh) signaling system for developing anticancer drugs; however, whether Smo may transmit GPCR-like signaling to activate the canon...

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Detalles Bibliográficos
Autores principales: Zhan, Xia, Wang, Juan, Liu, Yuan, Peng, Yuanqiu, Tan, Wenfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895738/
https://www.ncbi.nlm.nih.gov/pubmed/24393163
http://dx.doi.org/10.1186/1476-4598-13-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895738/
https://www.ncbi.nlm.nih.gov/pubmed/24393163
http://dx.doi.org/10.1186/1476-4598-13-4

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