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GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli
BACKGROUND: Smoothened (Smo), which possesses a structural similarity with classic G-protein coupled receptors (GPCR), is the most important molecular target in Hedgehog (Hh) signaling system for developing anticancer drugs; however, whether Smo may transmit GPCR-like signaling to activate the canon...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895738/ https://www.ncbi.nlm.nih.gov/pubmed/24393163 http://dx.doi.org/10.1186/1476-4598-13-4 |