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Neuronal aging: learning from C. elegans
The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique advantages in unraveling the molecular genetic network that regu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895751/ https://www.ncbi.nlm.nih.gov/pubmed/24325838 http://dx.doi.org/10.1186/1750-2187-8-14 |
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author | Chen, Chun-Hao Chen, Yen-Chih Jiang, Hao-Ching Chen, Chung-Kuan Pan, Chun-Liang |
author_facet | Chen, Chun-Hao Chen, Yen-Chih Jiang, Hao-Ching Chen, Chung-Kuan Pan, Chun-Liang |
author_sort | Chen, Chun-Hao |
collection | PubMed |
description | The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique advantages in unraveling the molecular genetic network that regulates the integrity of neuronal structures and functions during aging. In this review, we first summarize recent breakthroughs in the morphological and functional characterization of C. elegans neuronal aging. Age-associated morphological changes include age-dependent neurite branching, axon beading or swelling, axon defasciculation, progressive distortion of the neuronal soma, and early decline in presynaptic release function. We then discuss genetic pathways that modulate the speed of neuronal aging concordant with alteration in life span, such as insulin signaling, as well as cell-autonomous factors that promote neuronal integrity during senescence, including membrane activity and JNK/MAPK signaling. As a robust genetic model for aging, insights from C. elegans neuronal aging studies will contribute to our mechanistic understanding of human brain aging. |
format | Online Article Text |
id | pubmed-3895751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38957512014-01-21 Neuronal aging: learning from C. elegans Chen, Chun-Hao Chen, Yen-Chih Jiang, Hao-Ching Chen, Chung-Kuan Pan, Chun-Liang J Mol Signal Review The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique advantages in unraveling the molecular genetic network that regulates the integrity of neuronal structures and functions during aging. In this review, we first summarize recent breakthroughs in the morphological and functional characterization of C. elegans neuronal aging. Age-associated morphological changes include age-dependent neurite branching, axon beading or swelling, axon defasciculation, progressive distortion of the neuronal soma, and early decline in presynaptic release function. We then discuss genetic pathways that modulate the speed of neuronal aging concordant with alteration in life span, such as insulin signaling, as well as cell-autonomous factors that promote neuronal integrity during senescence, including membrane activity and JNK/MAPK signaling. As a robust genetic model for aging, insights from C. elegans neuronal aging studies will contribute to our mechanistic understanding of human brain aging. BioMed Central 2013-12-10 /pmc/articles/PMC3895751/ /pubmed/24325838 http://dx.doi.org/10.1186/1750-2187-8-14 Text en Copyright © 2013 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Chen, Chun-Hao Chen, Yen-Chih Jiang, Hao-Ching Chen, Chung-Kuan Pan, Chun-Liang Neuronal aging: learning from C. elegans |
title | Neuronal aging: learning from C. elegans |
title_full | Neuronal aging: learning from C. elegans |
title_fullStr | Neuronal aging: learning from C. elegans |
title_full_unstemmed | Neuronal aging: learning from C. elegans |
title_short | Neuronal aging: learning from C. elegans |
title_sort | neuronal aging: learning from c. elegans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895751/ https://www.ncbi.nlm.nih.gov/pubmed/24325838 http://dx.doi.org/10.1186/1750-2187-8-14 |
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