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ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload

Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, but its involvement in renal underexcretion (RUE) hyperuricemia, the most prevalent subtype, is not clearly explained so...

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Autores principales: Matsuo, Hirotaka, Nakayama, Akiyoshi, Sakiyama, Masayuki, Chiba, Toshinori, Shimizu, Seiko, Kawamura, Yusuke, Nakashima, Hiroshi, Nakamura, Takahiro, Takada, Yuzo, Oikawa, Yuji, Takada, Tappei, Nakaoka, Hirofumi, Abe, Junko, Inoue, Hiroki, Wakai, Kenji, Kawai, Sayo, Guang, Yin, Nakagawa, Hiroko, Ito, Toshimitsu, Niwa, Kazuki, Yamamoto, Ken, Sakurai, Yutaka, Suzuki, Hiroshi, Hosoya, Tatsuo, Ichida, Kimiyoshi, Shimizu, Toru, Shinomiya, Nariyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895923/
https://www.ncbi.nlm.nih.gov/pubmed/24441388
http://dx.doi.org/10.1038/srep03755
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author Matsuo, Hirotaka
Nakayama, Akiyoshi
Sakiyama, Masayuki
Chiba, Toshinori
Shimizu, Seiko
Kawamura, Yusuke
Nakashima, Hiroshi
Nakamura, Takahiro
Takada, Yuzo
Oikawa, Yuji
Takada, Tappei
Nakaoka, Hirofumi
Abe, Junko
Inoue, Hiroki
Wakai, Kenji
Kawai, Sayo
Guang, Yin
Nakagawa, Hiroko
Ito, Toshimitsu
Niwa, Kazuki
Yamamoto, Ken
Sakurai, Yutaka
Suzuki, Hiroshi
Hosoya, Tatsuo
Ichida, Kimiyoshi
Shimizu, Toru
Shinomiya, Nariyoshi
author_facet Matsuo, Hirotaka
Nakayama, Akiyoshi
Sakiyama, Masayuki
Chiba, Toshinori
Shimizu, Seiko
Kawamura, Yusuke
Nakashima, Hiroshi
Nakamura, Takahiro
Takada, Yuzo
Oikawa, Yuji
Takada, Tappei
Nakaoka, Hirofumi
Abe, Junko
Inoue, Hiroki
Wakai, Kenji
Kawai, Sayo
Guang, Yin
Nakagawa, Hiroko
Ito, Toshimitsu
Niwa, Kazuki
Yamamoto, Ken
Sakurai, Yutaka
Suzuki, Hiroshi
Hosoya, Tatsuo
Ichida, Kimiyoshi
Shimizu, Toru
Shinomiya, Nariyoshi
author_sort Matsuo, Hirotaka
collection PubMed
description Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, but its involvement in renal underexcretion (RUE) hyperuricemia, the most prevalent subtype, is not clearly explained so far. In this study, the association analysis with 644 hyperuricemia patients and 1,623 controls in male Japanese revealed that ABCG2 dysfunction significantly increased the risk of RUE hyperuricemia as well as overall and ROL hyperuricemia, according to the severity of impairment. ABCG2 dysfunction caused renal urate underexcretion and induced hyperuricemia even if the renal urate overload was not remarkable. These results show that ABCG2 plays physiologically important roles in both renal and extra-renal urate excretion mechanisms. Our findings indicate the importance of ABCG2 as a promising therapeutic and screening target of hyperuricemia and gout.
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spelling pubmed-38959232014-01-21 ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload Matsuo, Hirotaka Nakayama, Akiyoshi Sakiyama, Masayuki Chiba, Toshinori Shimizu, Seiko Kawamura, Yusuke Nakashima, Hiroshi Nakamura, Takahiro Takada, Yuzo Oikawa, Yuji Takada, Tappei Nakaoka, Hirofumi Abe, Junko Inoue, Hiroki Wakai, Kenji Kawai, Sayo Guang, Yin Nakagawa, Hiroko Ito, Toshimitsu Niwa, Kazuki Yamamoto, Ken Sakurai, Yutaka Suzuki, Hiroshi Hosoya, Tatsuo Ichida, Kimiyoshi Shimizu, Toru Shinomiya, Nariyoshi Sci Rep Article Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, but its involvement in renal underexcretion (RUE) hyperuricemia, the most prevalent subtype, is not clearly explained so far. In this study, the association analysis with 644 hyperuricemia patients and 1,623 controls in male Japanese revealed that ABCG2 dysfunction significantly increased the risk of RUE hyperuricemia as well as overall and ROL hyperuricemia, according to the severity of impairment. ABCG2 dysfunction caused renal urate underexcretion and induced hyperuricemia even if the renal urate overload was not remarkable. These results show that ABCG2 plays physiologically important roles in both renal and extra-renal urate excretion mechanisms. Our findings indicate the importance of ABCG2 as a promising therapeutic and screening target of hyperuricemia and gout. Nature Publishing Group 2014-01-20 /pmc/articles/PMC3895923/ /pubmed/24441388 http://dx.doi.org/10.1038/srep03755 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Matsuo, Hirotaka
Nakayama, Akiyoshi
Sakiyama, Masayuki
Chiba, Toshinori
Shimizu, Seiko
Kawamura, Yusuke
Nakashima, Hiroshi
Nakamura, Takahiro
Takada, Yuzo
Oikawa, Yuji
Takada, Tappei
Nakaoka, Hirofumi
Abe, Junko
Inoue, Hiroki
Wakai, Kenji
Kawai, Sayo
Guang, Yin
Nakagawa, Hiroko
Ito, Toshimitsu
Niwa, Kazuki
Yamamoto, Ken
Sakurai, Yutaka
Suzuki, Hiroshi
Hosoya, Tatsuo
Ichida, Kimiyoshi
Shimizu, Toru
Shinomiya, Nariyoshi
ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
title ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
title_full ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
title_fullStr ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
title_full_unstemmed ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
title_short ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
title_sort abcg2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895923/
https://www.ncbi.nlm.nih.gov/pubmed/24441388
http://dx.doi.org/10.1038/srep03755
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