ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload

Gout is a common disease which results from hyperuricemia. We have reported that the dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, but its involvement in renal underexcretion (RUE) hyperuricemia, the most prevalent subtype, is not clearly explained so...

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Detalles Bibliográficos
Autores principales: Matsuo, Hirotaka, Nakayama, Akiyoshi, Sakiyama, Masayuki, Chiba, Toshinori, Shimizu, Seiko, Kawamura, Yusuke, Nakashima, Hiroshi, Nakamura, Takahiro, Takada, Yuzo, Oikawa, Yuji, Takada, Tappei, Nakaoka, Hirofumi, Abe, Junko, Inoue, Hiroki, Wakai, Kenji, Kawai, Sayo, Guang, Yin, Nakagawa, Hiroko, Ito, Toshimitsu, Niwa, Kazuki, Yamamoto, Ken, Sakurai, Yutaka, Suzuki, Hiroshi, Hosoya, Tatsuo, Ichida, Kimiyoshi, Shimizu, Toru, Shinomiya, Nariyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895923/
https://www.ncbi.nlm.nih.gov/pubmed/24441388
http://dx.doi.org/10.1038/srep03755

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