Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics

In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated processes.

Detalles Bibliográficos
Autores principales: Chentsova, Anna, Kapourani, Era, Giannis, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896258/
https://www.ncbi.nlm.nih.gov/pubmed/24454558
http://dx.doi.org/10.3762/bjoc.10.2
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author Chentsova, Anna
Kapourani, Era
Giannis, Athanassios
author_facet Chentsova, Anna
Kapourani, Era
Giannis, Athanassios
author_sort Chentsova, Anna
collection PubMed
description In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated processes.
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spelling pubmed-38962582014-01-21 Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics Chentsova, Anna Kapourani, Era Giannis, Athanassios Beilstein J Org Chem Full Research Paper In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated processes. Beilstein-Institut 2014-01-03 /pmc/articles/PMC3896258/ /pubmed/24454558 http://dx.doi.org/10.3762/bjoc.10.2 Text en Copyright © 2014, Chentsova et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Chentsova, Anna
Kapourani, Era
Giannis, Athanassios
Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
title Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
title_full Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
title_fullStr Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
title_full_unstemmed Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
title_short Synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
title_sort synthesis of novel derivatives of 5-hydroxymethylcytosine and 5-formylcytosine as tools for epigenetics
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896258/
https://www.ncbi.nlm.nih.gov/pubmed/24454558
http://dx.doi.org/10.3762/bjoc.10.2
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