Long-Term Exposure of Mice to Nucleoside Analogues Disrupts Mitochondrial DNA Maintenance in Cortical Neurons

Nucleoside analogue reverse transcriptase inhibitor (NRTI), an integral component of highly active antiretroviral therapy (HAART), was widely used to inhibit HIV replication. Long-term exposure to NRTIs can result in mitochondrial toxicity which manifests as lipoatrophy, lactic acidosis, cardiomyopa...

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Detalles Bibliográficos
Autores principales: Zhang, Yulin, Song, Fengli, Gao, Ziyun, Ding, Wei, Qiao, Luxin, Yang, Sufang, Chen, Xi, Jin, Ronghua, Chen, Dexi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896403/
https://www.ncbi.nlm.nih.gov/pubmed/24465628
http://dx.doi.org/10.1371/journal.pone.0085637

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