Cargando…

Individual Globular Domains and Domain Unfolding Visualized in Overstretched Titin Molecules with Atomic Force Microscopy

Titin is a giant elastomeric protein responsible for the generation of passive muscle force. Mechanical force unfolds titin’s globular domains, but the exact structure of the overstretched titin molecule is not known. Here we analyzed, by using high-resolution atomic force microscopy, the structure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mártonfalvi, Zsolt, Kellermayer, Miklós
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896421/ https://www.ncbi.nlm.nih.gov/pubmed/24465745 http://dx.doi.org/10.1371/journal.pone.0085847

Ejemplares similares

Nanosurgical Manipulation of Titin and Its M-Complex
por: Sziklai, Dominik, et al.
Publicado: (2022)

Visualization of the polarity of isolated titin molecules: a single globular head on a long thin rod as the M band anchoring domain?
Publicado: (1989)

Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments
por: Trombitás, Karoly, et al.
Publicado: (1998)

Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)
por: Loescher, Christine M., et al.
Publicado: (2020)

Sequential Unfolding of Beta Helical Protein by Single-Molecule Atomic Force Microscopy
por: Alsteens, David, et al.
Publicado: (2013)

Dynamic Strength of Titin's Z-Disk End
por: Kollár, Veronika, et al.
Publicado: (2010)

Force spectroscopy and fluorescence microscopy of dsDNA–YOYO-1 complexes: implications for the structure of dsDNA in the overstretching region
por: Murade, Chandrashekhar U., et al.
Publicado: (2010)

Scooby-domain: prediction of globular domains in protein sequence
por: George, Richard A., et al.
Publicado: (2005)

Measurement of Globular Protein Molecules by Electron Microscopy
por: Hall, Cecil E.
Publicado: (1960)

Globular domain of adiponectin: promising target molecule for detection of atherosclerotic lesions
por: Almer, Gunter, et al.
Publicado: (2011)

Nonspecific Amyloid Aggregation of Chicken Smooth-Muscle Titin: In Vitro Investigations
por: Bobylev, Alexander G., et al.
Publicado: (2023)

Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain
por: Meirelles, Gabriela V, et al.
Publicado: (2011)

Two distinct overstretched DNA states
por: Fu, Hongxia, et al.
Publicado: (2010)

Elucidating the Role of Topological Constraint on the Structure of Overstretched DNA Using Fluorescence Polarization Microscopy
por: Backer, Adam S., et al.
Publicado: (2021)

Visualization and identification of single meteoritic organic molecules by atomic force microscopy
por: Kaiser, Katharina, et al.
Publicado: (2022)

Optimization of Quality Attributes and Atomic Force Microscopy Imaging of Reconstituted Nanodroplets in Baicalin Loaded Self-Nanoemulsifying Formulations
por: Jakab, Géza, et al.
Publicado: (2018)

Insight into the Unfolding Properties of Chd64, a Small, Single Domain Protein with a Globular Core and Disordered Tails
por: Tarczewska, Aneta, et al.
Publicado: (2015)

Measuring biological materials mechanics with atomic force microscopy ‐ Mechanical unfolding of biopolymers
por: Gil‐Redondo, Juan Carlos, et al.
Publicado: (2022)

Specific titin and myomesin domains stimulate myoblast proliferation
por: Kravchenko, Irina V., et al.
Publicado: (2016)

Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete’s Heart
por: Kellermayer, Dalma, et al.
Publicado: (2021)

Overstretching Expectations May Endanger the Success of the “Millennium Surgery”
por: Bender, Alwina, et al.
Publicado: (2022)

Single-particle virology
por: Kiss, Bálint, et al.
Publicado: (2020)

Complex Unfolding Kinetics of Single-Domain Proteins in the Presence of Force
por: Schlierf, Michael, et al.
Publicado: (2010)

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals
por: Ju, Lining, et al.
Publicado: (2016)

Titin N2A Domain and Its Interactions at the Sarcomere
por: Adewale, Adeleye O., et al.
Publicado: (2021)

Interdomain Linker Effect on the Mechanical Stability of Ig Domains in Titin
por: Tong, Bei, et al.
Publicado: (2022)

Direct visualization of the native structure of viroid RNAs at single-molecule resolution by atomic force microscopy
por: Moreno, M., et al.
Publicado: (2019)

Gene3D: Extensive prediction of globular domains in proteins
por: Lewis, Tony E, et al.
Publicado: (2018)

Gene3D: Extensive prediction of globular domains in proteins
por: Lewis, Tony E, et al.
Publicado: (2018)

Pipeline for transferring annotations between proteins beyond globular domains
por: Martínez‐Pérez, Elizabeth, et al.
Publicado: (2023)

Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis
por: Stergiou, Christos, et al.
Publicado: (2023)

Atomic force microscopy for single molecule characterisation of protein aggregation
por: Ruggeri, Francesco Simone, et al.
Publicado: (2019)

Conformation-regulated mechanosensory control via titin domains in cardiac muscle
por: Voelkel, Tobias, et al.
Publicado: (2011)

An Improved Strategy for Generating Forces in Steered Molecular Dynamics: The Mechanical Unfolding of Titin, e2lip3 and Ubiquitin
por: Ho, Bosco K., et al.
Publicado: (2010)

Removal of immunoglobulin-like domains from titin’s spring segment alters titin splicing in mouse skeletal muscle and causes myopathy
por: Buck, Danielle, et al.
Publicado: (2014)

Atomic force microscopy
por: Eaton, Peter, et al.
Publicado: (2010)

Visualization of DNA Damage and Protection by Atomic Force Microscopy in Liquid
por: Dai, Tinghui, et al.
Publicado: (2022)

Features of DNA–Montmorillonite Binding Visualized by Atomic Force Microscopy
por: Kraevsky, Sergey V., et al.
Publicado: (2023)

Single-Molecule Force Spectroscopy Studies of Missense Titin Mutations That Are Likely Causing Cardiomyopathy
por: Zuo, Jiacheng, et al.
Publicado: (2021)

Electronegativity determination of individual surface atoms by atomic force microscopy
por: Onoda, Jo, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bu0jq8ddut8pmn363pvv7a1lkn